DegronMD

Uniprot ID: O94854

Source protein: Microtubule-actin cross-linking factor 1, isoforms 6/7

Source gene: MACF1

Class: DEG_COP1_1

Location: 699:707

E3 ligase: COP1

DEGRON score: 0.9902

ASA_SCORE: 88.7889

COIL: 0.9398

CONS_SCORE: 0.6808

DSS_SCORE: 0.4036

HELIX: 0.0233

FCONS_SCORE: 1.4794

RIG_SCORE: 0.7478

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S699F	DO224815	BRCA	ICGC	SRTAAVPTV	DEG_COP1_1	0.7982
p.R700W	ACH-000961	Endometrial/Uterine Cancer	CCLE	SRTAAVPTV	DEG_COP1_1	0.7523
p.V704L	ACH-002120	Skin Cancer	CCLE	SRTAAVPTV	DEG_COP1_1	0.6765
p.S717I	TCGA-AP-A051	UCEC	TCGA	SRTAAVPTV	DEG_COP1_1	0.5
p.S717I	DO42673	UCEC	ICGC	SRTAAVPTV	DEG_COP1_1	0.5
p.Q696K	TCGA-95-7944	LUAD	TCGA	SRTAAVPTV	DEG_COP1_1	0.25
p.Q696K	DO25163	LUAD	ICGC	SRTAAVPTV	DEG_COP1_1	0.25
p.D712V	TCGA-DG-A2KH	CESC	TCGA	SRTAAVPTV	DEG_COP1_1	0.1944
p.D712V	DO51593	CESC	ICGC	SRTAAVPTV	DEG_COP1_1	0.1944
p.E689Q	TCGA-DK-A1AF	BLCA	TCGA	SRTAAVPTV	DEG_COP1_1	0.0556
p.E689Q	DO633	BLCA	ICGC	SRTAAVPTV	DEG_COP1_1	0.0556

Showing 1 to 11 of 11 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94854	Microtubule-actin cross-linking factor 1, isoforms 6/7	DEG_COP1_1	699:707	SRTAAVPTV	COP1	0.9902	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons