DegronMD

Uniprot ID: Q12888

Source protein: TP53-binding protein 1

Source gene: TP53BP1

Class: DEG_SCF_FBW7_1

Location: 667:674

E3 ligase: FBXW7

DEGRON score: 0.9959

ASA_SCORE: 90.7625

COIL: 0.9313

CONS_SCORE: 0.3464

DSS_SCORE: 0.8033

HELIX: 0.0336

FCONS_SCORE: 1.0356

RIG_SCORE: 0.6442

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P673S	TCGA-21-1079	LUSC	TCGA	IPETPCES	DEG_SCF_FBW7_1	0.6752
p.P673S	TCGA-D9-A4Z6	SKCM	TCGA	IPETPCES	DEG_SCF_FBW7_1	0.6752
p.P673S	TCGA-DA-A1IC	SKCM	TCGA	IPETPCES	DEG_SCF_FBW7_1	0.6752
p.P673S	TCGA-W3-AA1W	SKCM	TCGA	IPETPCES	DEG_SCF_FBW7_1	0.6752
p.L684H	TCGA-BR-8589	STAD	TCGA	IPETPCES	DEG_SCF_FBW7_1	0.0556
p.E668G	TCGA-CA-6717	COAD	TCGA	IPETPCES	DEG_SCF_FBW7_1	0.7199
p.I672F	TCGA-D9-A4Z3	SKCM	TCGA	IPETPCES	DEG_SCF_FBW7_1	0.7415
p.H659Y	TCGA-EE-A2GB	SKCM	TCGA	IPETPCES	DEG_SCF_FBW7_1	0.5556
p.L684P	TCGA-KB-A93J	STAD	TCGA	IPETPCES	DEG_SCF_FBW7_1	0.0556
p.S665L	TCGA-P3-A5Q5	HNSC	TCGA	IPETPCES	DEG_SCF_FBW7_1	0.2778
p.G681A	TCGA-ZF-A9R7	BLCA	TCGA	IPETPCES	DEG_SCF_FBW7_1	0.1389
p.G676A	DO219064	BLCA	ICGC	IPETPCES	DEG_SCF_FBW7_1	0.2778
p.E663G	DO8264	COAD	ICGC	IPETPCES	DEG_SCF_FBW7_1	0.2222
p.S660L	DO44450	HNSC	ICGC	IPETPCES	DEG_SCF_FBW7_1	0.5833
p.M684I	DO48489	KIRP	ICGC	IPETPCES	DEG_SCF_FBW7_1	0.0556
p.N683Y	DO50755	LICA	ICGC	IPETPCES	DEG_SCF_FBW7_1	0.0833
p.P668S	DO26846	LUSC	ICGC	IPETPCES	DEG_SCF_FBW7_1	0.5641
p.P668S	DO37430	SKCM	ICGC	IPETPCES	DEG_SCF_FBW7_1	0.5641
p.P668S	DO47485	SKCM	ICGC	IPETPCES	DEG_SCF_FBW7_1	0.5641
p.P668S	DO51277	SKCM	ICGC	IPETPCES	DEG_SCF_FBW7_1	0.5641
p.I667F	DO47555	SKCM	ICGC	IPETPCES	DEG_SCF_FBW7_1	0.7415
p.L679H	DO47813	STAD	ICGC	IPETPCES	DEG_SCF_FBW7_1	0.1944
p.L679P	DO222336	STAD	ICGC	IPETPCES	DEG_SCF_FBW7_1	0.1944
p.E682D	SIDM00596	Endometrial Carcinoma	GDSC	IPETPCES	DEG_SCF_FBW7_1	0.1111
p.E682D	ACH-000941	Endometrial/Uterine Cancer	CCLE	IPETPCES	DEG_SCF_FBW7_1	0.1111
p.E682D	ACH-001517	Endometrial/Uterine Cancer	CCLE	IPETPCES	DEG_SCF_FBW7_1	0.1111
p.E682D	HEC-1	endometrium	COSMIC	IPETPCES	DEG_SCF_FBW7_1	0.1111
p.E668Q	SIDM00158	Glioblastoma	GDSC	IPETPCES	DEG_SCF_FBW7_1	0.6744
p.E668Q	ACH-000623	Brain Cancer	CCLE	IPETPCES	DEG_SCF_FBW7_1	0.6744
p.G666V	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	IPETPCES	DEG_SCF_FBW7_1	0.3056
p.G666V	ACH-000813	Lung Cancer	CCLE	IPETPCES	DEG_SCF_FBW7_1	0.3056
p.E677D	HEC-1	endometrium	COSMIC	IPETPCES	DEG_SCF_FBW7_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IPETPCES

Degron related mutations and impact score

Drug responses associated with TP53BP1 mutations

All proteins holding degron of IPETPCES

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q12888	TP53-binding protein 1	DEG_SCF_FBW7_1	667:674	IPETPCES	FBXW7	0.9959	More...