DegronMD

Uniprot ID: Q9UBV4

Source protein: Protein Wnt-16

Source gene: WNT16

Class: LIG_APCC_ABBA_1

Location: 277:282

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8556

ASA_SCORE: 81.8167

COIL: 0.7587

CONS_SCORE: 0.556

DSS_SCORE: 0.491

HELIX: 0.234

FCONS_SCORE: 0.8671

RIG_SCORE: 0.7853

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q274K	TCGA-86-8669	LUAD	TCGA	IPIHKD	LIG_APCC_ABBA_1	0.25
p.I279V	TCGA-AY-6197	COAD	TCGA	IPIHKD	LIG_APCC_ABBA_1	0.5965
p.I279V	DO9956	COAD	ICGC	IPIHKD	LIG_APCC_ABBA_1	0.5965
p.R268C	TCGA-AZ-4315	COAD	TCGA	IPIHKD	LIG_APCC_ABBA_1	0.0833
p.R268C	DO8842	COAD	ICGC	IPIHKD	LIG_APCC_ABBA_1	0.0833
p.V287A	TCGA-B5-A3FA	UCEC	TCGA	IPIHKD	LIG_APCC_ABBA_1	0.1944
p.V287A	DO52402	UCEC	ICGC	IPIHKD	LIG_APCC_ABBA_1	0.1944
p.E271Q	TCGA-CV-5970	HNSC	TCGA	IPIHKD	LIG_APCC_ABBA_1	0.1667
p.I277L	TCGA-MV-A51V	BLCA	TCGA	IPIHKD	LIG_APCC_ABBA_1	0.6063
p.I267L	DO474	BLCA	ICGC	IPIHKD	LIG_APCC_ABBA_1	0.0556
p.R269S	DO228974	LICA	ICGC	IPIHKD	LIG_APCC_ABBA_1	0.1111
p.K271N	DO229019	LICA	ICGC	IPIHKD	LIG_APCC_ABBA_1	0.1667
p.D273Y	DO229034	LICA	ICGC	IPIHKD	LIG_APCC_ABBA_1	0.2222
p.E286Q	DO24920	LUAD	ICGC	IPIHKD	LIG_APCC_ABBA_1	0.2222
p.I277V	DO228414	MALY	ICGC	IPIHKD	LIG_APCC_ABBA_1	0.5965
p.D287A	DO30310	OV	ICGC	IPIHKD	LIG_APCC_ABBA_1	0.1944
p.D273H	SIDM00628	Breast Carcinoma	GDSC	IPIHKD	LIG_APCC_ABBA_1	0.2222
p.D273H	ACH-000849	Breast Cancer	CCLE	IPIHKD	LIG_APCC_ABBA_1	0.2222
p.D273H	MDA-MB-468	breast	COSMIC	IPIHKD	LIG_APCC_ABBA_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UBV4	Protein Wnt-16	LIG_APCC_ABBA_1	277:282	IPIHKD	APC,CDC20,FZR1	0.8556	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons