DegronMD - Q9UBV4(WNT16)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q274K	TCGA-86-8669	LUAD	TCGA	IPIHKD	LIG_APCC_ABBA_1	277:282	Mutation rewiring degron network	0.25
p.Q274K	TCGA-86-8669	LUAD	TCGA	KIPIHKD	LIG_APCC_ABBAyCdc20_2	276:282	Mutation rewiring degron network	0.2778
p.I279V	TCGA-AY-6197	COAD	TCGA	IPIHKD	LIG_APCC_ABBA_1	277:282	Mutation altering degron motif	0.5965
p.I279V	TCGA-AY-6197	COAD	TCGA	KIPIHKD	LIG_APCC_ABBAyCdc20_2	276:282	Mutation altering degron motif	0.5965
p.I279V	DO9956	COAD	ICGC	IPIHKD	LIG_APCC_ABBA_1	277:282	Mutation altering degron motif	0.5965
p.I279V	DO9956	COAD	ICGC	KIPIHKD	LIG_APCC_ABBAyCdc20_2	276:282	Mutation altering degron motif	0.5965
p.R268C	TCGA-AZ-4315	COAD	TCGA	IPIHKD	LIG_APCC_ABBA_1	277:282	Mutation rewiring degron network	0.0833
p.R268C	TCGA-AZ-4315	COAD	TCGA	KIPIHKD	LIG_APCC_ABBAyCdc20_2	276:282	Mutation rewiring degron network	0.1111
p.R268C	DO8842	COAD	ICGC	IPIHKD	LIG_APCC_ABBA_1	277:282	Mutation rewiring degron network	0.0833
p.R268C	DO8842	COAD	ICGC	KIPIHKD	LIG_APCC_ABBAyCdc20_2	276:282	Mutation rewiring degron network	0.1111
p.V287A	TCGA-B5-A3FA	UCEC	TCGA	IPIHKD	LIG_APCC_ABBA_1	277:282	Mutation rewiring degron network	0.1944
p.V287A	TCGA-B5-A3FA	UCEC	TCGA	KIPIHKD	LIG_APCC_ABBAyCdc20_2	276:282	Mutation rewiring degron network	0.1944
p.V287A	DO52402	UCEC	ICGC	IPIHKD	LIG_APCC_ABBA_1	277:282	Mutation rewiring degron network	0.1944
p.V287A	DO52402	UCEC	ICGC	KIPIHKD	LIG_APCC_ABBAyCdc20_2	276:282	Mutation rewiring degron network	0.1944
p.E271Q	TCGA-CV-5970	HNSC	TCGA	IPIHKD	LIG_APCC_ABBA_1	277:282	Mutation rewiring degron network	0.1667
p.E271Q	TCGA-CV-5970	HNSC	TCGA	KIPIHKD	LIG_APCC_ABBAyCdc20_2	276:282	Mutation rewiring degron network	0.1944
p.K276N	TCGA-EE-A29D	SKCM	TCGA	KIPIHKD	LIG_APCC_ABBAyCdc20_2	276:282	Mutation altering degron motif	0.6918
p.I277L	TCGA-MV-A51V	BLCA	TCGA	IPIHKD	LIG_APCC_ABBA_1	277:282	Mutation altering degron motif	0.6063
p.I277L	TCGA-MV-A51V	BLCA	TCGA	KIPIHKD	LIG_APCC_ABBAyCdc20_2	276:282	Mutation altering degron motif	0.6063
p.I267L	DO474	BLCA	ICGC	IPIHKD	LIG_APCC_ABBA_1	277:282	Mutation rewiring degron network	0.0556
p.I267L	DO474	BLCA	ICGC	KIPIHKD	LIG_APCC_ABBAyCdc20_2	276:282	Mutation rewiring degron network	0.0833
p.R269S	DO228974	LICA	ICGC	IPIHKD	LIG_APCC_ABBA_1	277:282	Mutation rewiring degron network	0.1111
p.R269S	DO228974	LICA	ICGC	KIPIHKD	LIG_APCC_ABBAyCdc20_2	276:282	Mutation rewiring degron network	0.1389
p.K271N	DO229019	LICA	ICGC	IPIHKD	LIG_APCC_ABBA_1	277:282	Mutation rewiring degron network	0.1667
p.K271N	DO229019	LICA	ICGC	KIPIHKD	LIG_APCC_ABBAyCdc20_2	276:282	Mutation rewiring degron network	0.1944
p.D273Y	DO229034	LICA	ICGC	IPIHKD	LIG_APCC_ABBA_1	277:282	Mutation rewiring degron network	0.2222
p.D273Y	DO229034	LICA	ICGC	KIPIHKD	LIG_APCC_ABBAyCdc20_2	276:282	Mutation rewiring degron network	0.25
p.E286Q	DO24920	LUAD	ICGC	IPIHKD	LIG_APCC_ABBA_1	277:282	Mutation rewiring degron network	0.2222
p.E286Q	DO24920	LUAD	ICGC	KIPIHKD	LIG_APCC_ABBAyCdc20_2	276:282	Mutation rewiring degron network	0.2222
p.I277V	DO228414	MALY	ICGC	IPIHKD	LIG_APCC_ABBA_1	277:282	Mutation altering degron motif	0.5965
p.I277V	DO228414	MALY	ICGC	KIPIHKD	LIG_APCC_ABBAyCdc20_2	276:282	Mutation altering degron motif	0.5965
p.D287A	DO30310	OV	ICGC	IPIHKD	LIG_APCC_ABBA_1	277:282	Mutation rewiring degron network	0.1944
p.D287A	DO30310	OV	ICGC	KIPIHKD	LIG_APCC_ABBAyCdc20_2	276:282	Mutation rewiring degron network	0.1944
p.K266N	DO38123	SKCM	ICGC	KIPIHKD	LIG_APCC_ABBAyCdc20_2	276:282	Mutation substituting flanking lysine	0.1667
p.D273H	SIDM00628	Breast Carcinoma	GDSC	IPIHKD	LIG_APCC_ABBA_1	277:282	Mutation rewiring degron network	0.2222
p.D273H	SIDM00628	Breast Carcinoma	GDSC	KIPIHKD	LIG_APCC_ABBAyCdc20_2	276:282	Mutation rewiring degron network	0.25
p.D273H	ACH-000849	Breast Cancer	CCLE	IPIHKD	LIG_APCC_ABBA_1	277:282	Mutation rewiring degron network	0.2222
p.D273H	ACH-000849	Breast Cancer	CCLE	KIPIHKD	LIG_APCC_ABBAyCdc20_2	276:282	Mutation rewiring degron network	0.25
p.D273H	MDA-MB-468	breast	COSMIC	IPIHKD	LIG_APCC_ABBA_1	277:282	Mutation rewiring degron network	0.2222
p.D273H	MDA-MB-468	breast	COSMIC	KIPIHKD	LIG_APCC_ABBAyCdc20_2	276:282	Mutation rewiring degron network	0.25

Kaplan plot for WNT16 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WNT16

UniProt ID: Q9UBV4

Entrez ID: 51384

Protein name: Protein Wnt-16

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for WNT16 in