DegronMD

Uniprot ID: Q9UBV4

Source protein: Protein Wnt-16

Source gene: WNT16

Class: LIG_APCC_ABBAyCdc20_2

Location: 276:282

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6159

ASA_SCORE: 90.0714

COIL: 0.7813

CONS_SCORE: 0.5495

DSS_SCORE: 0.4934

HELIX: 0.2043

FCONS_SCORE: 0.8544

RIG_SCORE: 0.7758

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q274K	TCGA-86-8669	LUAD	TCGA	KIPIHKD	LIG_APCC_ABBAyCdc20_2	0.2778
p.I279V	TCGA-AY-6197	COAD	TCGA	KIPIHKD	LIG_APCC_ABBAyCdc20_2	0.5965
p.I279V	DO9956	COAD	ICGC	KIPIHKD	LIG_APCC_ABBAyCdc20_2	0.5965
p.R268C	TCGA-AZ-4315	COAD	TCGA	KIPIHKD	LIG_APCC_ABBAyCdc20_2	0.1111
p.R268C	DO8842	COAD	ICGC	KIPIHKD	LIG_APCC_ABBAyCdc20_2	0.1111
p.V287A	TCGA-B5-A3FA	UCEC	TCGA	KIPIHKD	LIG_APCC_ABBAyCdc20_2	0.1944
p.V287A	DO52402	UCEC	ICGC	KIPIHKD	LIG_APCC_ABBAyCdc20_2	0.1944
p.E271Q	TCGA-CV-5970	HNSC	TCGA	KIPIHKD	LIG_APCC_ABBAyCdc20_2	0.1944
p.K276N	TCGA-EE-A29D	SKCM	TCGA	KIPIHKD	LIG_APCC_ABBAyCdc20_2	0.6918
p.I277L	TCGA-MV-A51V	BLCA	TCGA	KIPIHKD	LIG_APCC_ABBAyCdc20_2	0.6063
p.I267L	DO474	BLCA	ICGC	KIPIHKD	LIG_APCC_ABBAyCdc20_2	0.0833
p.R269S	DO228974	LICA	ICGC	KIPIHKD	LIG_APCC_ABBAyCdc20_2	0.1389
p.K271N	DO229019	LICA	ICGC	KIPIHKD	LIG_APCC_ABBAyCdc20_2	0.1944
p.D273Y	DO229034	LICA	ICGC	KIPIHKD	LIG_APCC_ABBAyCdc20_2	0.25
p.E286Q	DO24920	LUAD	ICGC	KIPIHKD	LIG_APCC_ABBAyCdc20_2	0.2222
p.I277V	DO228414	MALY	ICGC	KIPIHKD	LIG_APCC_ABBAyCdc20_2	0.5965
p.D287A	DO30310	OV	ICGC	KIPIHKD	LIG_APCC_ABBAyCdc20_2	0.1944
p.K266N	DO38123	SKCM	ICGC	KIPIHKD	LIG_APCC_ABBAyCdc20_2	0.1667
p.D273H	SIDM00628	Breast Carcinoma	GDSC	KIPIHKD	LIG_APCC_ABBAyCdc20_2	0.25
p.D273H	ACH-000849	Breast Cancer	CCLE	KIPIHKD	LIG_APCC_ABBAyCdc20_2	0.25
p.D273H	MDA-MB-468	breast	COSMIC	KIPIHKD	LIG_APCC_ABBAyCdc20_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UBV4	Protein Wnt-16	LIG_APCC_ABBAyCdc20_2	276:282	KIPIHKD	APC,CDC20,FZR1	0.6159	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons