DegronMD

Uniprot ID: Q8N5Y2

Source protein: Male-specific lethal 3 homolog

Source gene: MSL3

Class: DEG_SCF_FBW7_2

Location: 402:409

E3 ligase: FBXW7

DEGRON score: 0.8242

ASA_SCORE: 89.1

COIL: 0.8428

CONS_SCORE: 0.294

DSS_SCORE: 0.5351

HELIX: 0.0901

FCONS_SCORE: 0.9268

RIG_SCORE: 0.6437

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S399F	TCGA-BR-7717	STAD	TCGA	IPLTPSKE	DEG_SCF_FBW7_2	0.6944
p.K408N	TCGA-CN-6010	HNSC	TCGA	IPLTPSKE	DEG_SCF_FBW7_2	0.5806
p.A415V	TCGA-E7-A97Q	BLCA	TCGA	IPLTPSKE	DEG_SCF_FBW7_2	0.1667
p.A403V	DO219022	BLCA	ICGC	IPLTPSKE	DEG_SCF_FBW7_2	0.6936
p.E415K	DO2401	BRCA	ICGC	IPLTPSKE	DEG_SCF_FBW7_2	0.1667
p.K396N	DO14766	HNSC	ICGC	IPLTPSKE	DEG_SCF_FBW7_2	0.6111
p.F393L	DO22403	LGG	ICGC	IPLTPSKE	DEG_SCF_FBW7_2	0.0833
p.S404R	DO45426	LUSC	ICGC	IPLTPSKE	DEG_SCF_FBW7_2	0.7427
p.V405M	DO46657	PAAD	ICGC	IPLTPSKE	DEG_SCF_FBW7_2	0.7208
p.V405M	DO43755	UCEC	ICGC	IPLTPSKE	DEG_SCF_FBW7_2	0.7208
p.P398L	DO47619	SKCM	ICGC	IPLTPSKE	DEG_SCF_FBW7_2	0.6667
p.Y406H	DO42023	UCEC	ICGC	IPLTPSKE	DEG_SCF_FBW7_2	0.7229
p.R409I	DO42280	UCEC	ICGC	IPLTPSKE	DEG_SCF_FBW7_2	0.8102
p.R409I	DO41488	UCEC	ICGC	IPLTPSKE	DEG_SCF_FBW7_2	0.8102
p.P406A	SIDM00832	Colorectal Carcinoma	GDSC	IPLTPSKE	DEG_SCF_FBW7_2	0.7503
p.P406A	ACH-000680	Colon/Colorectal Cancer	CCLE	IPLTPSKE	DEG_SCF_FBW7_2	0.7503
p.P406A	SW948	large_intestine	COSMIC	IPLTPSKE	DEG_SCF_FBW7_2	0.7503
p.P401H	SIDM00596	Endometrial Carcinoma	GDSC	IPLTPSKE	DEG_SCF_FBW7_2	0.3056
p.P401H	ACH-000941	Endometrial/Uterine Cancer	CCLE	IPLTPSKE	DEG_SCF_FBW7_2	0.3056
p.P401H	ACH-000954	Endometrial/Uterine Cancer	CCLE	IPLTPSKE	DEG_SCF_FBW7_2	0.3056
p.P401H	ACH-001517	Endometrial/Uterine Cancer	CCLE	IPLTPSKE	DEG_SCF_FBW7_2	0.3056
p.P401H	HEC-1	endometrium	COSMIC	IPLTPSKE	DEG_SCF_FBW7_2	0.3056
p.Q411E	SIDM00767	Small Cell Lung Carcinoma	GDSC	IPLTPSKE	DEG_SCF_FBW7_2	0.7222
p.Q411E	NCI-H187	lung	COSMIC	IPLTPSKE	DEG_SCF_FBW7_2	0.7222
p.P394A	SW948	large_intestine	COSMIC	IPLTPSKE	DEG_SCF_FBW7_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N5Y2	Male-specific lethal 3 homolog	DEG_SCF_FBW7_2	402:409	IPLTPSKE	FBXW7	0.8242	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IPLTPSKE

Degron related mutations and impact score

Drug responses associated with MSL3 mutations

All proteins holding degron of IPLTPSKE