DegronMD - Q8N5Y2(MSL3)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R103C	TCGA-24-2281	OV	TCGA	KRCRLPGVD	DEG_APCC_DBOX_1	102:110	Mutation altering degron motif	0.8301
p.R103C	TCGA-BR-8487	STAD	TCGA	KRCRLPGVD	DEG_APCC_DBOX_1	102:110	Mutation altering degron motif	0.8301
p.R105M	TCGA-A5-A1OF	UCEC	TCGA	KRCRLPGVD	DEG_APCC_DBOX_1	102:110	Mutation altering degron motif	0.7521
p.R93C	TCGA-AZ-4615	COAD	TCGA	KRCRLPGVD	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.0833
p.D376N	TCGA-B0-4852	KIRC	TCGA	LFLHLE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.1111
p.D376N	TCGA-B0-4852	KIRC	TCGA	KLFLHLE	LIG_APCC_ABBAyCdc20_2	383:389	Mutation rewiring degron network	0.1389
p.E119G	TCGA-B5-A3FC	UCEC	TCGA	KRCRLPGVD	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.0833
p.A379T	TCGA-B5-A3FC	UCEC	TCGA	LFLHLE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.1944
p.A379T	TCGA-B5-A3FC	UCEC	TCGA	KLFLHLE	LIG_APCC_ABBAyCdc20_2	383:389	Mutation rewiring degron network	0.2222
p.A379T	DO41871	UCEC	ICGC	LFLHLE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.1944
p.A379T	DO41871	UCEC	ICGC	KLFLHLE	LIG_APCC_ABBAyCdc20_2	383:389	Mutation rewiring degron network	0.2222
p.S399F	TCGA-BR-7717	STAD	TCGA	IPLTPSKE	DEG_SCF_FBW7_2	402:409	Mutation blocking phosphorylation signal	0.6944
p.S399F	TCGA-BR-7717	STAD	TCGA	LFLHLE	LIG_APCC_ABBA_1	384:389	Mutation blocking phosphorylation signal	0.5
p.S399F	TCGA-BR-7717	STAD	TCGA	KLFLHLE	LIG_APCC_ABBAyCdc20_2	383:389	Mutation blocking phosphorylation signal	0.5
p.R103H	TCGA-BR-8680	STAD	TCGA	KRCRLPGVD	DEG_APCC_DBOX_1	102:110	Mutation altering degron motif	0.8244
p.R103H	TCGA-CA-5796	COAD	TCGA	KRCRLPGVD	DEG_APCC_DBOX_1	102:110	Mutation altering degron motif	0.8244
p.L113I	TCGA-CD-5801	STAD	TCGA	KRCRLPGVD	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.25
p.K408N	TCGA-CN-6010	HNSC	TCGA	IPLTPSKE	DEG_SCF_FBW7_2	402:409	Mutation altering degron motif	0.5806
p.P317T	TCGA-DD-A73A	LIHC	TCGA	PSTPQST	DEG_SCF_FBW7_1	317:323	Mutation altering degron motif	0.7031
p.P317T	DO48478	LIHC	ICGC	PSTPQST	DEG_SCF_FBW7_1	317:323	Mutation altering degron motif	0.7031
p.K391E	TCGA-DK-A1A7	BLCA	TCGA	LFLHLE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.2778
p.K391E	TCGA-DK-A1A7	BLCA	TCGA	KLFLHLE	LIG_APCC_ABBAyCdc20_2	383:389	Mutation rewiring degron network	0.2778
p.S380I	TCGA-DU-6392	LGG	TCGA	LFLHLE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.2222
p.S380I	TCGA-DU-6392	LGG	TCGA	KLFLHLE	LIG_APCC_ABBAyCdc20_2	383:389	Mutation rewiring degron network	0.25
p.S380I	DO22237	LGG	ICGC	LFLHLE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.2222
p.S380I	DO22237	LGG	ICGC	KLFLHLE	LIG_APCC_ABBAyCdc20_2	383:389	Mutation rewiring degron network	0.25
p.A415V	TCGA-E7-A97Q	BLCA	TCGA	IPLTPSKE	DEG_SCF_FBW7_2	402:409	Mutation rewiring degron network	0.1667
p.G108D	TCGA-EO-A22R	UCEC	TCGA	KRCRLPGVD	DEG_APCC_DBOX_1	102:110	Mutation altering degron motif	0.6087
p.G108D	DO42713	UCEC	ICGC	KRCRLPGVD	DEG_APCC_DBOX_1	102:110	Mutation altering degron motif	0.6087
p.G330S	TCGA-EO-A22U	UCEC	TCGA	PSTPQST	DEG_SCF_FBW7_1	317:323	Mutation rewiring degron network	0.1389
p.T319M	TCGA-F5-6465	READ	TCGA	PSTPQST	DEG_SCF_FBW7_1	317:323	Mutation altering degron motif	0.8534
p.T319M	DO233272	GACA	ICGC	PSTPQST	DEG_SCF_FBW7_1	317:323	Mutation altering degron motif	0.8534
p.T319M	DO37324	READ	ICGC	PSTPQST	DEG_SCF_FBW7_1	317:323	Mutation altering degron motif	0.8534
p.S318P	TCGA-FI-A2D5	UCEC	TCGA	PSTPQST	DEG_SCF_FBW7_1	317:323	Mutation altering degron motif	0.6752
p.S318P	DO41331	UCEC	ICGC	PSTPQST	DEG_SCF_FBW7_1	317:323	Mutation altering degron motif	0.6752
p.P332A	TCGA-XF-A9SY	BLCA	TCGA	PSTPQST	DEG_SCF_FBW7_1	317:323	Mutation rewiring degron network	0.0833
p.P332A	DO51918	BLCA	ICGC	PSTPQST	DEG_SCF_FBW7_1	317:323	Mutation rewiring degron network	0.0833
p.A403V	DO219022	BLCA	ICGC	IPLTPSKE	DEG_SCF_FBW7_2	402:409	Mutation altering degron motif	0.6936
p.S391G	DO483	BLCA	ICGC	LFLHLE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.2778
p.S391G	DO483	BLCA	ICGC	KLFLHLE	LIG_APCC_ABBAyCdc20_2	383:389	Mutation rewiring degron network	0.2778
p.E377Q	DO225207	BRCA	ICGC	LFLHLE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.1389
p.E377Q	DO225207	BRCA	ICGC	KLFLHLE	LIG_APCC_ABBAyCdc20_2	383:389	Mutation rewiring degron network	0.1667
p.E415K	DO2401	BRCA	ICGC	IPLTPSKE	DEG_SCF_FBW7_2	402:409	Mutation rewiring degron network	0.1667
p.S120P	DO3317	BRCA	ICGC	KRCRLPGVD	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.0556
p.E107K	DO222817	BTCA	ICGC	KRCRLPGVD	DEG_APCC_DBOX_1	102:110	Mutation altering degron motif	0.7022
p.D98Y	DO51990	CLLE	ICGC	KRCRLPGVD	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.2222
p.G318S	DO233898	GACA	ICGC	PSTPQST	DEG_SCF_FBW7_1	317:323	Mutation altering degron motif	0.6993
p.G318S	DO43755	UCEC	ICGC	PSTPQST	DEG_SCF_FBW7_1	317:323	Mutation altering degron motif	0.6993
p.K396N	DO14766	HNSC	ICGC	IPLTPSKE	DEG_SCF_FBW7_2	402:409	Mutation blocking phosphorylation signal	0.6111
p.K396N	DO14766	HNSC	ICGC	LFLHLE	LIG_APCC_ABBA_1	384:389	Mutation blocking phosphorylation signal	0.5833
p.K396N	DO14766	HNSC	ICGC	KLFLHLE	LIG_APCC_ABBAyCdc20_2	383:389	Mutation blocking phosphorylation signal	0.5833
p.F393L	DO22403	LGG	ICGC	IPLTPSKE	DEG_SCF_FBW7_2	402:409	Mutation rewiring degron network	0.0833
p.F393L	DO22403	LGG	ICGC	LFLHLE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.2222
p.F393L	DO22403	LGG	ICGC	KLFLHLE	LIG_APCC_ABBAyCdc20_2	383:389	Mutation rewiring degron network	0.2222
p.E324V	DO228815	LICA	ICGC	PSTPQST	DEG_SCF_FBW7_1	317:323	Mutation rewiring degron network	0.3056
p.E324V	SIDM01608	Endometrial Carcinoma	GDSC	PSTPQST	DEG_SCF_FBW7_1	317:323	Mutation rewiring degron network	0.3056
p.E324V	ACH-000990	Endometrial/Uterine Cancer	CCLE	PSTPQST	DEG_SCF_FBW7_1	317:323	Mutation rewiring degron network	0.3056
p.G108V	DO229019	LICA	ICGC	KRCRLPGVD	DEG_APCC_DBOX_1	102:110	Mutation altering degron motif	0.6421
p.S119I	DO229019	LICA	ICGC	KRCRLPGVD	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.0833
p.M381I	DO229034	LICA	ICGC	LFLHLE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.25
p.M381I	DO229034	LICA	ICGC	KLFLHLE	LIG_APCC_ABBAyCdc20_2	383:389	Mutation rewiring degron network	0.2778
p.D113N	DO229050	LICA	ICGC	KRCRLPGVD	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.25
p.S404R	DO45426	LUSC	ICGC	IPLTPSKE	DEG_SCF_FBW7_2	402:409	Mutation altering degron motif	0.7427
p.L117S	DO222595	MELA	ICGC	KRCRLPGVD	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.1389
p.V405M	DO46657	PAAD	ICGC	IPLTPSKE	DEG_SCF_FBW7_2	402:409	Mutation altering degron motif	0.7208
p.V405M	DO43755	UCEC	ICGC	IPLTPSKE	DEG_SCF_FBW7_2	402:409	Mutation altering degron motif	0.7208
p.T380I	DO35642	PBCA	ICGC	LFLHLE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.2222
p.T380I	DO35642	PBCA	ICGC	KLFLHLE	LIG_APCC_ABBAyCdc20_2	383:389	Mutation rewiring degron network	0.25
p.P398L	DO47619	SKCM	ICGC	IPLTPSKE	DEG_SCF_FBW7_2	402:409	Mutation blocking phosphorylation signal	0.6667
p.P398L	DO47619	SKCM	ICGC	LFLHLE	LIG_APCC_ABBA_1	384:389	Mutation blocking phosphorylation signal	0.5278
p.P398L	DO47619	SKCM	ICGC	KLFLHLE	LIG_APCC_ABBAyCdc20_2	383:389	Mutation blocking phosphorylation signal	0.5278
p.L101I	DO38563	STAD	ICGC	KRCRLPGVD	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.3056
p.S387F	DO38412	STAD	ICGC	LFLHLE	LIG_APCC_ABBA_1	384:389	Mutation altering degron motif	0.7982
p.S387F	DO38412	STAD	ICGC	KLFLHLE	LIG_APCC_ABBAyCdc20_2	383:389	Mutation altering degron motif	0.7982
p.P95L	DO229211	THCA	ICGC	KRCRLPGVD	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.1389
p.P391T	DO231338	THCA	ICGC	LFLHLE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.2778
p.P391T	DO231338	THCA	ICGC	KLFLHLE	LIG_APCC_ABBAyCdc20_2	383:389	Mutation rewiring degron network	0.2778
p.Y406H	DO42023	UCEC	ICGC	IPLTPSKE	DEG_SCF_FBW7_2	402:409	Mutation altering degron motif	0.7229
p.R409I	DO42280	UCEC	ICGC	IPLTPSKE	DEG_SCF_FBW7_2	402:409	Mutation altering degron motif	0.8102
p.R409I	DO41488	UCEC	ICGC	IPLTPSKE	DEG_SCF_FBW7_2	402:409	Mutation altering degron motif	0.8102
p.E107G	DO41871	UCEC	ICGC	KRCRLPGVD	DEG_APCC_DBOX_1	102:110	Mutation altering degron motif	0.7199
p.R93M	DO42568	UCEC	ICGC	KRCRLPGVD	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.0833
p.D110Y	DO41379	UCEC	ICGC	KRCRLPGVD	DEG_APCC_DBOX_1	102:110	Mutation altering degron motif	0.6214
p.P406A	SIDM00832	Colorectal Carcinoma	GDSC	IPLTPSKE	DEG_SCF_FBW7_2	402:409	Mutation altering degron motif	0.7503
p.P406A	ACH-000680	Colon/Colorectal Cancer	CCLE	IPLTPSKE	DEG_SCF_FBW7_2	402:409	Mutation altering degron motif	0.7503
p.P406A	SW948	large intestine	COSMIC	IPLTPSKE	DEG_SCF_FBW7_2	402:409	Mutation altering degron motif	0.7503
p.A92D	SIDM00942	Oral Cavity Carcinoma	GDSC	KRCRLPGVD	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.0556
p.A92D	ACH-000518	Head and Neck Cancer	CCLE	KRCRLPGVD	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.0556
p.A92D	CAL-33	upper aerodigestive tract	COSMIC	KRCRLPGVD	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.0556
p.P401H	SIDM00596	Endometrial Carcinoma	GDSC	IPLTPSKE	DEG_SCF_FBW7_2	402:409	Mutation rewiring degron network	0.3056
p.P401H	ACH-000941	Endometrial/Uterine Cancer	CCLE	IPLTPSKE	DEG_SCF_FBW7_2	402:409	Mutation rewiring degron network	0.3056
p.P401H	ACH-000954	Endometrial/Uterine Cancer	CCLE	IPLTPSKE	DEG_SCF_FBW7_2	402:409	Mutation rewiring degron network	0.3056
p.P401H	ACH-001517	Endometrial/Uterine Cancer	CCLE	IPLTPSKE	DEG_SCF_FBW7_2	402:409	Mutation rewiring degron network	0.3056
p.P401H	HEC-1	endometrium	COSMIC	IPLTPSKE	DEG_SCF_FBW7_2	402:409	Mutation rewiring degron network	0.3056
p.Q411E	SIDM00767	Small Cell Lung Carcinoma	GDSC	IPLTPSKE	DEG_SCF_FBW7_2	402:409	Mutation blocking phosphorylation signal	0.7222
p.Q411E	NCI-H187	lung	COSMIC	IPLTPSKE	DEG_SCF_FBW7_2	402:409	Mutation blocking phosphorylation signal	0.7222
p.R309Q	GP5d	large intestine	COSMIC	PSTPQST	DEG_SCF_FBW7_1	317:323	Mutation rewiring degron network	0.1111
p.P389H	HEC-1	endometrium	COSMIC	LFLHLE	LIG_APCC_ABBA_1	384:389	Mutation altering degron motif	0.7694
p.P389H	HEC-1	endometrium	COSMIC	KLFLHLE	LIG_APCC_ABBAyCdc20_2	383:389	Mutation altering degron motif	0.7694
p.A98V	EC-GI-10	oesophagus	COSMIC	KRCRLPGVD	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.2222
p.P394A	SW948	large intestine	COSMIC	IPLTPSKE	DEG_SCF_FBW7_2	402:409	Mutation rewiring degron network	0.1111
p.P394A	SW948	large intestine	COSMIC	LFLHLE	LIG_APCC_ABBA_1	384:389	Mutation rewiring degron network	0.1944
p.P394A	SW948	large intestine	COSMIC	KLFLHLE	LIG_APCC_ABBAyCdc20_2	383:389	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MSL3

UniProt ID: Q8N5Y2

Entrez ID: 10943

Protein name: Male-specific lethal 3 homolog (Male-specific lethal-3 homolog 1) (Male-specific lethal-3 protein-like 1) (MSL3-like 1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for MSL3 in