DegronMD

Uniprot ID: Q8N5Y2

Source protein: Male-specific lethal 3 homolog

Source gene: MSL3

Class: DEG_SCF_FBW7_1

Location: 317:323

E3 ligase: FBXW7

DEGRON score: 0.9728

ASA_SCORE: 82.2

COIL: 0.91

CONS_SCORE: 0.3262

DSS_SCORE: 0.8675

HELIX: 0.0517

FCONS_SCORE: 0.9679

RIG_SCORE: 0.504

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P317T	TCGA-DD-A73A	LIHC	TCGA	PSTPQST	DEG_SCF_FBW7_1	0.7031
p.P317T	DO48478	LIHC	ICGC	PSTPQST	DEG_SCF_FBW7_1	0.7031
p.G330S	TCGA-EO-A22U	UCEC	TCGA	PSTPQST	DEG_SCF_FBW7_1	0.1389
p.T319M	TCGA-F5-6465	READ	TCGA	PSTPQST	DEG_SCF_FBW7_1	0.8534
p.T319M	DO233272	GACA	ICGC	PSTPQST	DEG_SCF_FBW7_1	0.8534
p.T319M	DO37324	READ	ICGC	PSTPQST	DEG_SCF_FBW7_1	0.8534
p.S318P	TCGA-FI-A2D5	UCEC	TCGA	PSTPQST	DEG_SCF_FBW7_1	0.6752
p.S318P	DO41331	UCEC	ICGC	PSTPQST	DEG_SCF_FBW7_1	0.6752
p.P332A	TCGA-XF-A9SY	BLCA	TCGA	PSTPQST	DEG_SCF_FBW7_1	0.0833
p.P332A	DO51918	BLCA	ICGC	PSTPQST	DEG_SCF_FBW7_1	0.0833
p.G318S	DO233898	GACA	ICGC	PSTPQST	DEG_SCF_FBW7_1	0.6993
p.G318S	DO43755	UCEC	ICGC	PSTPQST	DEG_SCF_FBW7_1	0.6993
p.E324V	DO228815	LICA	ICGC	PSTPQST	DEG_SCF_FBW7_1	0.3056
p.E324V	SIDM01608	Endometrial Carcinoma	GDSC	PSTPQST	DEG_SCF_FBW7_1	0.3056
p.E324V	ACH-000990	Endometrial/Uterine Cancer	CCLE	PSTPQST	DEG_SCF_FBW7_1	0.3056
p.R309Q	GP5d	large_intestine	COSMIC	PSTPQST	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N5Y2	Male-specific lethal 3 homolog	DEG_SCF_FBW7_1	317:323	PSTPQST	FBXW7	0.9728	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons