DegronMD

Uniprot ID: Q8N5Y2

Source protein: Male-specific lethal 3 homolog

Source gene: MSL3

Class: DEG_APCC_DBOX_1

Location: 102:110

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.556

ASA_SCORE: 99.7222

COIL: 0.7908

CONS_SCORE: 0.318

DSS_SCORE: 0.5241

HELIX: 0.1

FCONS_SCORE: 0.9971

RIG_SCORE: 0.7167

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R103C	TCGA-24-2281	OV	TCGA	KRCRLPGVD	DEG_APCC_DBOX_1	0.8301
p.R103C	TCGA-BR-8487	STAD	TCGA	KRCRLPGVD	DEG_APCC_DBOX_1	0.8301
p.R105M	TCGA-A5-A1OF	UCEC	TCGA	KRCRLPGVD	DEG_APCC_DBOX_1	0.7521
p.R93C	TCGA-AZ-4615	COAD	TCGA	KRCRLPGVD	DEG_APCC_DBOX_1	0.0833
p.E119G	TCGA-B5-A3FC	UCEC	TCGA	KRCRLPGVD	DEG_APCC_DBOX_1	0.0833
p.R103H	TCGA-BR-8680	STAD	TCGA	KRCRLPGVD	DEG_APCC_DBOX_1	0.8244
p.R103H	TCGA-CA-5796	COAD	TCGA	KRCRLPGVD	DEG_APCC_DBOX_1	0.8244
p.L113I	TCGA-CD-5801	STAD	TCGA	KRCRLPGVD	DEG_APCC_DBOX_1	0.25
p.G108D	TCGA-EO-A22R	UCEC	TCGA	KRCRLPGVD	DEG_APCC_DBOX_1	0.6087
p.G108D	DO42713	UCEC	ICGC	KRCRLPGVD	DEG_APCC_DBOX_1	0.6087
p.S120P	DO3317	BRCA	ICGC	KRCRLPGVD	DEG_APCC_DBOX_1	0.0556
p.E107K	DO222817	BTCA	ICGC	KRCRLPGVD	DEG_APCC_DBOX_1	0.7022
p.D98Y	DO51990	CLLE	ICGC	KRCRLPGVD	DEG_APCC_DBOX_1	0.2222
p.G108V	DO229019	LICA	ICGC	KRCRLPGVD	DEG_APCC_DBOX_1	0.6421
p.S119I	DO229019	LICA	ICGC	KRCRLPGVD	DEG_APCC_DBOX_1	0.0833
p.D113N	DO229050	LICA	ICGC	KRCRLPGVD	DEG_APCC_DBOX_1	0.25
p.L117S	DO222595	MELA	ICGC	KRCRLPGVD	DEG_APCC_DBOX_1	0.1389
p.L101I	DO38563	STAD	ICGC	KRCRLPGVD	DEG_APCC_DBOX_1	0.3056
p.P95L	DO229211	THCA	ICGC	KRCRLPGVD	DEG_APCC_DBOX_1	0.1389
p.E107G	DO41871	UCEC	ICGC	KRCRLPGVD	DEG_APCC_DBOX_1	0.7199
p.R93M	DO42568	UCEC	ICGC	KRCRLPGVD	DEG_APCC_DBOX_1	0.0833
p.D110Y	DO41379	UCEC	ICGC	KRCRLPGVD	DEG_APCC_DBOX_1	0.6214
p.A92D	SIDM00942	Oral Cavity Carcinoma	GDSC	KRCRLPGVD	DEG_APCC_DBOX_1	0.0556
p.A92D	ACH-000518	Head and Neck Cancer	CCLE	KRCRLPGVD	DEG_APCC_DBOX_1	0.0556
p.A92D	CAL-33	upper_aerodigestive_tract	COSMIC	KRCRLPGVD	DEG_APCC_DBOX_1	0.0556
p.A98V	EC-GI-10	oesophagus	COSMIC	KRCRLPGVD	DEG_APCC_DBOX_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N5Y2	Male-specific lethal 3 homolog	DEG_APCC_DBOX_1	102:110	KRCRLPGVD	APC,CDC20,FZR1	0.556	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KRCRLPGVD

Degron related mutations and impact score

Drug responses associated with MSL3 mutations

All proteins holding degron of KRCRLPGVD