DegronMD

Uniprot ID: Q8N5Y2

Source protein: Male-specific lethal 3 homolog

Source gene: MSL3

Class: LIG_APCC_ABBA_1

Location: 384:389

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8582

ASA_SCORE: 83.2333

COIL: 0.4337

CONS_SCORE: 0.3418

DSS_SCORE: 0.6216

HELIX: 0.3657

FCONS_SCORE: 1.053

RIG_SCORE: 0.7377

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D376N	TCGA-B0-4852	KIRC	TCGA	LFLHLE	LIG_APCC_ABBA_1	0.1111
p.A379T	TCGA-B5-A3FC	UCEC	TCGA	LFLHLE	LIG_APCC_ABBA_1	0.1944
p.A379T	DO41871	UCEC	ICGC	LFLHLE	LIG_APCC_ABBA_1	0.1944
p.S399F	TCGA-BR-7717	STAD	TCGA	LFLHLE	LIG_APCC_ABBA_1	0.5
p.K391E	TCGA-DK-A1A7	BLCA	TCGA	LFLHLE	LIG_APCC_ABBA_1	0.2778
p.S380I	TCGA-DU-6392	LGG	TCGA	LFLHLE	LIG_APCC_ABBA_1	0.2222
p.S380I	DO22237	LGG	ICGC	LFLHLE	LIG_APCC_ABBA_1	0.2222
p.S391G	DO483	BLCA	ICGC	LFLHLE	LIG_APCC_ABBA_1	0.2778
p.E377Q	DO225207	BRCA	ICGC	LFLHLE	LIG_APCC_ABBA_1	0.1389
p.K396N	DO14766	HNSC	ICGC	LFLHLE	LIG_APCC_ABBA_1	0.5833
p.F393L	DO22403	LGG	ICGC	LFLHLE	LIG_APCC_ABBA_1	0.2222
p.M381I	DO229034	LICA	ICGC	LFLHLE	LIG_APCC_ABBA_1	0.25
p.T380I	DO35642	PBCA	ICGC	LFLHLE	LIG_APCC_ABBA_1	0.2222
p.P398L	DO47619	SKCM	ICGC	LFLHLE	LIG_APCC_ABBA_1	0.5278
p.S387F	DO38412	STAD	ICGC	LFLHLE	LIG_APCC_ABBA_1	0.7982
p.P391T	DO231338	THCA	ICGC	LFLHLE	LIG_APCC_ABBA_1	0.2778
p.P389H	HEC-1	endometrium	COSMIC	LFLHLE	LIG_APCC_ABBA_1	0.7694
p.P394A	SW948	large_intestine	COSMIC	LFLHLE	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N5Y2	Male-specific lethal 3 homolog	LIG_APCC_ABBA_1	384:389	LFLHLE	APC,CDC20,FZR1	0.8582	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons