DegronMD

Uniprot ID: Q8IZP0

Source protein: Abl interactor 1

Source gene: ABI1

Class: LIG_APCC_ABBA_1

Location: 404:409

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5407

ASA_SCORE: 88.1

COIL: 0.8823

CONS_SCORE: 0.3837

DSS_SCORE: 0.9273

HELIX: 0.0962

FCONS_SCORE: 0.6801

RIG_SCORE: 0.5653

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P396L	TCGA-22-5477	LUSC	TCGA	IPMFDD	LIG_APCC_ABBA_1	0.1111
p.P414S	TCGA-BH-A0H9	BRCA	TCGA	IPMFDD	LIG_APCC_ABBA_1	0.1944
p.P405L	TCGA-OR-A5KV	ACC	TCGA	IPMFDD	LIG_APCC_ABBA_1	0.6471
p.K412N	DO8264	COAD	ICGC	IPMFDD	LIG_APCC_ABBA_1	0.25
p.K412N	DO40884	UCEC	ICGC	IPMFDD	LIG_APCC_ABBA_1	0.25
p.K412N	DO43041	UCEC	ICGC	IPMFDD	LIG_APCC_ABBA_1	0.25
p.K412N	DO41903	UCEC	ICGC	IPMFDD	LIG_APCC_ABBA_1	0.25
p.K412N	DO41799	UCEC	ICGC	IPMFDD	LIG_APCC_ABBA_1	0.25
p.K412N	DO43907	UCEC	ICGC	IPMFDD	LIG_APCC_ABBA_1	0.25
p.Y402C	DO233156	GACA	ICGC	IPMFDD	LIG_APCC_ABBA_1	0.2778
p.G405W	DO37543	SKCM	ICGC	IPMFDD	LIG_APCC_ABBA_1	0.7825
p.P407H	DO37405	SKCM	ICGC	IPMFDD	LIG_APCC_ABBA_1	0.7694
p.P411T	DO37438	SKCM	ICGC	IPMFDD	LIG_APCC_ABBA_1	0.2778
p.G405V	DO38001	SKCM	ICGC	IPMFDD	LIG_APCC_ABBA_1	0.7532
p.P416L	SIDM00871	Non-Cancerous	GDSC	IPMFDD	LIG_APCC_ABBA_1	0.1389
p.P416L	SIDM00872	Breast Carcinoma	GDSC	IPMFDD	LIG_APCC_ABBA_1	0.1389
p.P416L	ACH-000859	Breast Cancer	CCLE	IPMFDD	LIG_APCC_ABBA_1	0.1389
p.P416L	ACH-002384	Non-Cancerous	CCLE	IPMFDD	LIG_APCC_ABBA_1	0.1389
p.M411I	DU-145	prostate	COSMIC	IPMFDD	LIG_APCC_ABBA_1	0.2778
p.M406I	DU-145	prostate	COSMIC	IPMFDD	LIG_APCC_ABBA_1	0.6507
p.M412I	DU-145	prostate	COSMIC	IPMFDD	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZP0	Abl interactor 1	LIG_APCC_ABBA_1	404:409	IPMFDD	APC,CDC20,FZR1	0.5407	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons