DegronMD - Q8IZP0(ABI1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P396L	TCGA-22-5477	LUSC	TCGA	IPMFDD	LIG_APCC_ABBA_1	404:409	Mutation rewiring degron network	0.1111
p.R106Q	TCGA-AP-A1DV	UCEC	TCGA	VDIHKE	LIG_APCC_ABBA_1	97:102	Mutation rewiring degron network	0.2222
p.R106Q	TCGA-BR-8680	STAD	TCGA	VDIHKE	LIG_APCC_ABBA_1	97:102	Mutation rewiring degron network	0.2222
p.R106Q	DO222762	COCA	ICGC	VDIHKE	LIG_APCC_ABBA_1	97:102	Mutation rewiring degron network	0.2222
p.R106Q	DO47769	STAD	ICGC	VDIHKE	LIG_APCC_ABBA_1	97:102	Mutation rewiring degron network	0.2222
p.R106Q	DO43186	UCEC	ICGC	VDIHKE	LIG_APCC_ABBA_1	97:102	Mutation rewiring degron network	0.2222
p.R106Q	SIDM01154	T-Lymphoblastic Leukemia	GDSC	VDIHKE	LIG_APCC_ABBA_1	97:102	Mutation rewiring degron network	0.2222
p.R106Q	ACH-000953	Leukemia	CCLE	VDIHKE	LIG_APCC_ABBA_1	97:102	Mutation rewiring degron network	0.2222
p.R106Q	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	VDIHKE	LIG_APCC_ABBA_1	97:102	Mutation rewiring degron network	0.2222
p.P414S	TCGA-BH-A0H9	BRCA	TCGA	IPMFDD	LIG_APCC_ABBA_1	404:409	Mutation rewiring degron network	0.1944
p.P405L	TCGA-OR-A5KV	ACC	TCGA	IPMFDD	LIG_APCC_ABBA_1	404:409	Mutation altering degron motif	0.6471
p.K412N	DO8264	COAD	ICGC	IPMFDD	LIG_APCC_ABBA_1	404:409	Mutation rewiring degron network	0.25
p.K412N	DO40884	UCEC	ICGC	IPMFDD	LIG_APCC_ABBA_1	404:409	Mutation rewiring degron network	0.25
p.K412N	DO43041	UCEC	ICGC	IPMFDD	LIG_APCC_ABBA_1	404:409	Mutation rewiring degron network	0.25
p.K412N	DO41903	UCEC	ICGC	IPMFDD	LIG_APCC_ABBA_1	404:409	Mutation rewiring degron network	0.25
p.K412N	DO41799	UCEC	ICGC	IPMFDD	LIG_APCC_ABBA_1	404:409	Mutation rewiring degron network	0.25
p.K412N	DO43907	UCEC	ICGC	IPMFDD	LIG_APCC_ABBA_1	404:409	Mutation rewiring degron network	0.25
p.Y402C	DO233156	GACA	ICGC	IPMFDD	LIG_APCC_ABBA_1	404:409	Mutation rewiring degron network	0.2778
p.G405W	DO37543	SKCM	ICGC	IPMFDD	LIG_APCC_ABBA_1	404:409	Mutation altering degron motif	0.7825
p.P407H	DO37405	SKCM	ICGC	IPMFDD	LIG_APCC_ABBA_1	404:409	Mutation altering degron motif	0.7694
p.P411T	DO37438	SKCM	ICGC	IPMFDD	LIG_APCC_ABBA_1	404:409	Mutation rewiring degron network	0.2778
p.G405V	DO38001	SKCM	ICGC	IPMFDD	LIG_APCC_ABBA_1	404:409	Mutation altering degron motif	0.7532
p.P416L	SIDM00871	Non-Cancerous	GDSC	IPMFDD	LIG_APCC_ABBA_1	404:409	Mutation rewiring degron network	0.1389
p.P416L	SIDM00872	Breast Carcinoma	GDSC	IPMFDD	LIG_APCC_ABBA_1	404:409	Mutation rewiring degron network	0.1389
p.P416L	ACH-000859	Breast Cancer	CCLE	IPMFDD	LIG_APCC_ABBA_1	404:409	Mutation rewiring degron network	0.1389
p.P416L	ACH-002384	Non-Cancerous	CCLE	IPMFDD	LIG_APCC_ABBA_1	404:409	Mutation rewiring degron network	0.1389
p.L112S	ACH-001611	Brain Cancer	CCLE	VDIHKE	LIG_APCC_ABBA_1	97:102	Mutation rewiring degron network	0.0556
p.M411I	DU-145	prostate	COSMIC	IPMFDD	LIG_APCC_ABBA_1	404:409	Mutation rewiring degron network	0.2778
p.M406I	DU-145	prostate	COSMIC	IPMFDD	LIG_APCC_ABBA_1	404:409	Mutation altering degron motif	0.6507
p.N99T	COLO-320-HSR	large intestine	COSMIC	VDIHKE	LIG_APCC_ABBA_1	97:102	Mutation altering degron motif	0.7055
p.M412I	DU-145	prostate	COSMIC	IPMFDD	LIG_APCC_ABBA_1	404:409	Mutation rewiring degron network	0.25

Kaplan plot for ABI1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ABI1

UniProt ID: Q8IZP0

Entrez ID: 10006

Protein name: Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ABI1 in