DegronMD

Uniprot ID: Q8IZP0

Source protein: Abl interactor 1

Source gene: ABI1

Class: LIG_APCC_ABBA_1

Location: 97:102

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5411

ASA_SCORE: 70.15

COIL: 0.1242

CONS_SCORE: 0.6395

DSS_SCORE: 0.3455

HELIX: 0.8637

FCONS_SCORE: 1.1623

RIG_SCORE: 0.807

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R106Q	TCGA-AP-A1DV	UCEC	TCGA	VDIHKE	LIG_APCC_ABBA_1	0.2222
p.R106Q	TCGA-BR-8680	STAD	TCGA	VDIHKE	LIG_APCC_ABBA_1	0.2222
p.R106Q	DO222762	COCA	ICGC	VDIHKE	LIG_APCC_ABBA_1	0.2222
p.R106Q	DO47769	STAD	ICGC	VDIHKE	LIG_APCC_ABBA_1	0.2222
p.R106Q	DO43186	UCEC	ICGC	VDIHKE	LIG_APCC_ABBA_1	0.2222
p.R106Q	SIDM01154	T-Lymphoblastic Leukemia	GDSC	VDIHKE	LIG_APCC_ABBA_1	0.2222
p.R106Q	ACH-000953	Leukemia	CCLE	VDIHKE	LIG_APCC_ABBA_1	0.2222
p.R106Q	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	VDIHKE	LIG_APCC_ABBA_1	0.2222
p.L112S	ACH-001611	Brain Cancer	CCLE	VDIHKE	LIG_APCC_ABBA_1	0.0556
p.N99T	COLO-320-HSR	large_intestine	COSMIC	VDIHKE	LIG_APCC_ABBA_1	0.7055

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IZP0	Abl interactor 1	LIG_APCC_ABBA_1	97:102	VDIHKE	APC,CDC20,FZR1	0.5411	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons