DegronMD

Uniprot ID: Q6V0I7

Source protein: Protocadherin Fat 4

Source gene: FAT4

Class: LIG_APCC_ABBA_1

Location: 4562:4567

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9577

ASA_SCORE: 72.0167

COIL: 0.874

CONS_SCORE: 0.2544

DSS_SCORE: 0.7017

HELIX: 0.0697

FCONS_SCORE: 0.8917

RIG_SCORE: 0.6449

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T4570I	TCGA-AY-6386	COAD	TCGA	IPPYGD	LIG_APCC_ABBA_1	0.25
p.G4577E	TCGA-BF-AAOX	SKCM	TCGA	IPPYGD	LIG_APCC_ABBA_1	0.0556
p.F4556C	TCGA-CA-6717	COAD	TCGA	IPPYGD	LIG_APCC_ABBA_1	0.1667
p.D4560E	TCGA-D5-6530	COAD	TCGA	IPPYGD	LIG_APCC_ABBA_1	0.2778
p.P4564S	TCGA-EB-A41A	SKCM	TCGA	IPPYGD	LIG_APCC_ABBA_1	0.6752
p.P4559L	TCGA-EB-A6QZ	SKCM	TCGA	IPPYGD	LIG_APCC_ABBA_1	0.25
p.D4557N	TCGA-OD-A75X	SKCM	TCGA	IPPYGD	LIG_APCC_ABBA_1	0.1944
p.P4564L	TCGA-YD-A89C	SKCM	TCGA	IPPYGD	LIG_APCC_ABBA_1	0.6471
p.P4564L	ACH-001566	Skin Cancer	CCLE	IPPYGD	LIG_APCC_ABBA_1	0.6471
p.E4552K	SIDM00860	Head and Neck Carcinoma	GDSC	IPPYGD	LIG_APCC_ABBA_1	0.0556
p.E4552K	ACH-000846	Head and Neck Cancer	CCLE	IPPYGD	LIG_APCC_ABBA_1	0.0556
p.E4552K	FADU	upper_aerodigestive_tract	COSMIC	IPPYGD	LIG_APCC_ABBA_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6V0I7	Protocadherin Fat 4	LIG_APCC_ABBA_1	4562:4567	IPPYGD	APC,CDC20,FZR1	0.9577	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons