DegronMD

Uniprot ID: Q9BZF2

Source protein: Oxysterol-binding protein-related protein 7

Source gene: OSBPL7

Class: DEG_SIAH_1

Location: 224:232

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9965

ASA_SCORE: 74.4667

COIL: 0.9

CONS_SCORE: 0.3044

DSS_SCORE: 0.5114

HELIX: 0.0512

FCONS_SCORE: 0.9124

RIG_SCORE: 0.6645

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R223Q	TCGA-D1-A103	UCEC	TCGA	IPSAPVIPT	DEG_SIAH_1	0.3056
p.R223Q	DO42312	UCEC	ICGC	IPSAPVIPT	DEG_SIAH_1	0.3056
p.P242L	DO222395	MELA	ICGC	IPSAPVIPT	DEG_SIAH_1	0.0556
p.A235V	SIDM01175	Other Sarcomas	GDSC	IPSAPVIPT	DEG_SIAH_1	0.25
p.A235V	SW684	soft_tissue	COSMIC	IPSAPVIPT	DEG_SIAH_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BZF2	Oxysterol-binding protein-related protein 7	DEG_SIAH_1	224:232	IPSAPVIPT	SIAH1,SIAH2,SIAH3	0.9965	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons