DegronMD - Q9BZF2(OSBPL7)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E383K	TCGA-06-5416	GBM	TCGA	LTPQLS	DEG_SCF_FBW7_1	384:389	Mutation rewiring degron network	0.3056
p.E383K	DO10880	GBM	ICGC	LTPQLS	DEG_SCF_FBW7_1	384:389	Mutation rewiring degron network	0.3056
p.R382P	TCGA-17-Z059	LUAD	TCGA	LTPQLS	DEG_SCF_FBW7_1	384:389	Mutation rewiring degron network	0.2778
p.R223Q	TCGA-D1-A103	UCEC	TCGA	IPSAPVIPT	DEG_SIAH_1	224:232	Mutation rewiring degron network	0.3056
p.R223Q	DO42312	UCEC	ICGC	IPSAPVIPT	DEG_SIAH_1	224:232	Mutation rewiring degron network	0.3056
p.S389L	TCGA-DA-A1I5	SKCM	TCGA	LTPQLS	DEG_SCF_FBW7_1	384:389	Mutation altering degron motif	0.7667
p.S389L	TCGA-EY-A5W2	UCEC	TCGA	LTPQLS	DEG_SCF_FBW7_1	384:389	Mutation altering degron motif	0.7667
p.S389L	DO222572	MELA	ICGC	LTPQLS	DEG_SCF_FBW7_1	384:389	Mutation altering degron motif	0.7667
p.S389L	DO37447	SKCM	ICGC	LTPQLS	DEG_SCF_FBW7_1	384:389	Mutation altering degron motif	0.7667
p.S389L	DO48177	UCEC	ICGC	LTPQLS	DEG_SCF_FBW7_1	384:389	Mutation altering degron motif	0.7667
p.P386H	TCGA-EE-A2GH	SKCM	TCGA	LTPQLS	DEG_SCF_FBW7_1	384:389	Mutation altering degron motif	0.7694
p.P386H	DO37643	SKCM	ICGC	LTPQLS	DEG_SCF_FBW7_1	384:389	Mutation altering degron motif	0.7694
p.M379T	DO233767	GACA	ICGC	LTPQLS	DEG_SCF_FBW7_1	384:389	Mutation rewiring degron network	0.1944
p.A397D	DO229009	LICA	ICGC	LTPQLS	DEG_SCF_FBW7_1	384:389	Mutation rewiring degron network	0.1111
p.P242L	DO222395	MELA	ICGC	IPSAPVIPT	DEG_SIAH_1	224:232	Mutation rewiring degron network	0.0556
p.L396F	DO229462	SKCA	ICGC	LTPQLS	DEG_SCF_FBW7_1	384:389	Mutation rewiring degron network	0.1389
p.A235V	SIDM01175	Other Sarcomas	GDSC	IPSAPVIPT	DEG_SIAH_1	224:232	Mutation rewiring degron network	0.25
p.A235V	SW684	soft tissue	COSMIC	IPSAPVIPT	DEG_SIAH_1	224:232	Mutation rewiring degron network	0.25
p.S392N	SIDM00660	Colorectal Carcinoma	GDSC	LTPQLS	DEG_SCF_FBW7_1	384:389	Mutation rewiring degron network	0.25
p.S392N	ACH-000985	Colon/Colorectal Cancer	CCLE	LTPQLS	DEG_SCF_FBW7_1	384:389	Mutation rewiring degron network	0.25
p.S392N	LS-411N	large intestine	COSMIC	LTPQLS	DEG_SCF_FBW7_1	384:389	Mutation rewiring degron network	0.25
p.Q387K	SIDM00210	Ovarian Carcinoma	GDSC	LTPQLS	DEG_SCF_FBW7_1	384:389	Mutation altering degron motif	0.5833
p.T385A	SIDM01608	Endometrial Carcinoma	GDSC	LTPQLS	DEG_SCF_FBW7_1	384:389	Mutation altering degron motif	0.7139
p.T385A	ACH-000990	Endometrial/Uterine Cancer	CCLE	LTPQLS	DEG_SCF_FBW7_1	384:389	Mutation altering degron motif	0.7139

Kaplan plot for OSBPL7 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

OSBPL7

UniProt ID: Q9BZF2

Entrez ID: 114881

Protein name: Oxysterol-binding protein-related protein 7 (ORP-7) (OSBP-related protein 7)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for OSBPL7 in