DegronMD

Uniprot ID: Q9BZF2

Source protein: Oxysterol-binding protein-related protein 7

Source gene: OSBPL7

Class: DEG_SCF_FBW7_1

Location: 384:389

E3 ligase: FBXW7

DEGRON score: 0.9747

ASA_SCORE: 73

COIL: 0.7385

CONS_SCORE: 0.3663

DSS_SCORE: 0.3491

HELIX: 0.2028

FCONS_SCORE: 1.0746

RIG_SCORE: 0.7537

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E383K	TCGA-06-5416	GBM	TCGA	LTPQLS	DEG_SCF_FBW7_1	0.3056
p.E383K	DO10880	GBM	ICGC	LTPQLS	DEG_SCF_FBW7_1	0.3056
p.R382P	TCGA-17-Z059	LUAD	TCGA	LTPQLS	DEG_SCF_FBW7_1	0.2778
p.S389L	TCGA-DA-A1I5	SKCM	TCGA	LTPQLS	DEG_SCF_FBW7_1	0.7667
p.S389L	TCGA-EY-A5W2	UCEC	TCGA	LTPQLS	DEG_SCF_FBW7_1	0.7667
p.S389L	DO222572	MELA	ICGC	LTPQLS	DEG_SCF_FBW7_1	0.7667
p.S389L	DO37447	SKCM	ICGC	LTPQLS	DEG_SCF_FBW7_1	0.7667
p.S389L	DO48177	UCEC	ICGC	LTPQLS	DEG_SCF_FBW7_1	0.7667
p.P386H	TCGA-EE-A2GH	SKCM	TCGA	LTPQLS	DEG_SCF_FBW7_1	0.7694
p.P386H	DO37643	SKCM	ICGC	LTPQLS	DEG_SCF_FBW7_1	0.7694
p.M379T	DO233767	GACA	ICGC	LTPQLS	DEG_SCF_FBW7_1	0.1944
p.A397D	DO229009	LICA	ICGC	LTPQLS	DEG_SCF_FBW7_1	0.1111
p.L396F	DO229462	SKCA	ICGC	LTPQLS	DEG_SCF_FBW7_1	0.1389
p.S392N	SIDM00660	Colorectal Carcinoma	GDSC	LTPQLS	DEG_SCF_FBW7_1	0.25
p.S392N	ACH-000985	Colon/Colorectal Cancer	CCLE	LTPQLS	DEG_SCF_FBW7_1	0.25
p.S392N	LS-411N	large_intestine	COSMIC	LTPQLS	DEG_SCF_FBW7_1	0.25
p.Q387K	SIDM00210	Ovarian Carcinoma	GDSC	LTPQLS	DEG_SCF_FBW7_1	0.5833
p.T385A	SIDM01608	Endometrial Carcinoma	GDSC	LTPQLS	DEG_SCF_FBW7_1	0.7139
p.T385A	ACH-000990	Endometrial/Uterine Cancer	CCLE	LTPQLS	DEG_SCF_FBW7_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9BZF2	Oxysterol-binding protein-related protein 7	DEG_SCF_FBW7_1	384:389	LTPQLS	FBXW7	0.9747	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons