DegronMD

Uniprot ID: Q685J3

Source protein: Mucin-17

Source gene: MUC17

Class: DEG_SCF_FBW7_1

Location: 3941:3948

E3 ligase: FBXW7

DEGRON score: 0.967

ASA_SCORE: 88.5125

COIL: 0.9129

CONS_SCORE: 0.5236

DSS_SCORE: 0.4013

HELIX: 0.0123

FCONS_SCORE: 1

RIG_SCORE: 0.7727

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A3956E	TCGA-39-5030	LUSC	TCGA	IPSTPVTS	DEG_SCF_FBW7_1	0.1111
p.A3956E	DO7418	CLLE	ICGC	IPSTPVTS	DEG_SCF_FBW7_1	0.1111
p.A3956E	DO27176	LUSC	ICGC	IPSTPVTS	DEG_SCF_FBW7_1	0.1111
p.T3947N	TCGA-44-6147	LUAD	TCGA	IPSTPVTS	DEG_SCF_FBW7_1	0.5944
p.T3947N	DO24740	LUAD	ICGC	IPSTPVTS	DEG_SCF_FBW7_1	0.5944
p.E3931D	TCGA-55-A4DG	LUAD	TCGA	IPSTPVTS	DEG_SCF_FBW7_1	0.0556
p.E3931D	DO26337	LUAD	ICGC	IPSTPVTS	DEG_SCF_FBW7_1	0.0556
p.T3957I	TCGA-AA-A01I	COAD	TCGA	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.T3957I	DO10510	COAD	ICGC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.P3935L	TCGA-B5-A11E	UCEC	TCGA	IPSTPVTS	DEG_SCF_FBW7_1	0.1667
p.P3935L	DO23250	LINC	ICGC	IPSTPVTS	DEG_SCF_FBW7_1	0.1667
p.P3935L	DO41644	UCEC	ICGC	IPSTPVTS	DEG_SCF_FBW7_1	0.1667
p.T3937A	TCGA-VQ-A8PX	STAD	TCGA	IPSTPVTS	DEG_SCF_FBW7_1	0.2222
p.T3937A	DO51778	STAD	ICGC	IPSTPVTS	DEG_SCF_FBW7_1	0.2222
p.G3932R	DO229003	COCA	ICGC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	DO229005	COCA	ICGC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	DO229480	LAML	ICGC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	DO231075	LUSC	ICGC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00450	Acute Myeloid Leukemia	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00608	Plasma Cell Myeloma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00437	Acute Myeloid Leukemia	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM01034	B-Lymphoblastic Leukemia	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00586	Hepatocellular Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00435	Acute Myeloid Leukemia	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00545	Melanoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00234	Other Solid Cancers	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00232	Kidney Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00611	Kidney Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00075	Non-Cancerous	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM01197	Colorectal Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00781	Colorectal Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00367	Small Cell Lung Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00291	Melanoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00370	T-Lymphoblastic Leukemia	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00315	Glioblastoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00308	Chronic Myelogenous Leukemia	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00362	Burkitt's Lymphoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00231	Kidney Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM01259	B-Lymphoblastic Leukemia	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00193	Colorectal Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00573	Glioblastoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00592	Oral Cavity Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00355	Non-Small Cell Lung Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00350	Head and Neck Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM01181	Hepatocellular Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00364	B-Lymphoblastic Leukemia	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00238	Ovarian Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00568	Gastric Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00282	Colorectal Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00195	Ewing's Sarcoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00596	Endometrial Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM01045	Endometrial Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00375	Head and Neck Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00489	Oral Cavity Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00292	Small Cell Lung Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00294	Small Cell Lung Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00252	Biliary Tract Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00237	Non-Small Cell Lung Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00276	Biliary Tract Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00298	Squamous Cell Lung Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00502	B-Lymphoblastic Leukemia	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00567	Other Solid Cancers	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00247	Gastric Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM01653	Non-Cancerous	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00357	Small Cell Lung Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00347	Esophageal Squamous Cell Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM01210	Glioblastoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00207	Glioblastoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00549	B-Lymphoblastic Leukemia	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00561	Other Blood Cancers	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00249	Esophageal Squamous Cell Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM01217	Other Blood Cancers	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00271	Gastric Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00368	Small Cell Lung Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00566	Oral Cavity Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00217	Colorectal Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00380	Acute Myeloid Leukemia	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00289	B-Lymphoblastic Leukemia	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00363	Acute Myeloid Leukemia	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00316	Glioblastoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00274	Gastric Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00603	Head and Neck Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00273	Glioblastoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00359	Colorectal Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00531	Pancreatic Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM01439	Hepatocellular Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00192	Colorectal Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM01728	Endometrial Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM01612	Endometrial Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM01617	Endometrial Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM01570	Ovarian Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM01577	Plasma Cell Myeloma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00169	Head and Neck Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00158	Glioblastoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM01472	Hepatocellular Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM01573	Plasma Cell Myeloma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00780	Colorectal Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM01446	Glioblastoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM01447	Glioblastoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM01691	Chronic Myelogenous Leukemia	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM01450	Gastric Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM01448	Head and Neck Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM01454	Kidney Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM01321	Pancreatic Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM01378	Ovarian Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM01782	Oral Cavity Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM01685	B-Lymphoblastic Leukemia	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM01694	B-Lymphoblastic Leukemia	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00016	Neuroblastoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM01442	Glioma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00162	Biliary Tract Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	SIDM00159	Biliary Tract Carcinoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932R	Mewo	skin	COSMIC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.T3938A	DO228732	GACA	ICGC	IPSTPVTS	DEG_SCF_FBW7_1	0.25
p.T3938A	DO42673	UCEC	ICGC	IPSTPVTS	DEG_SCF_FBW7_1	0.25
p.V3946I	DO233731	GACA	ICGC	IPSTPVTS	DEG_SCF_FBW7_1	0.5965
p.D3952Y	DO229027	LICA	ICGC	IPSTPVTS	DEG_SCF_FBW7_1	0.2222
p.G3932E	SIDM00545	Melanoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932E	ACH-000987	Skin Cancer	CCLE	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.G3932E	Mewo	skin	COSMIC	IPSTPVTS	DEG_SCF_FBW7_1	0.0833
p.T3934I	SIDM00845	Burkitt's Lymphoma	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.1389
p.T3934I	SIDM00493	Other Solid Cancers	GDSC	IPSTPVTS	DEG_SCF_FBW7_1	0.1389
p.A3951V	ACH-001786	Colon/Colorectal Cancer	CCLE	IPSTPVTS	DEG_SCF_FBW7_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IPSTPVTS

Degron related mutations and impact score

Drug responses associated with MUC17 mutations

All proteins holding degron of IPSTPVTS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q685J3	Mucin-17	DEG_SCF_FBW7_1	3941:3948	IPSTPVTS	FBXW7	0.967	More...