DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SCF_FBW7_1

Location: 4646:4652

E3 ligase: FBXW7

DEGRON score: 0.9763

ASA_SCORE: 86.0143

COIL: 0.8633

CONS_SCORE: 0

DSS_SCORE: 0.3347

HELIX: 0.0144

FCONS_SCORE: 0

RIG_SCORE: 0.7575

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T4653K	TCGA-28-1747	GBM	TCGA	IPTPAQS	DEG_SCF_FBW7_1	0.3056
p.T4653K	TCGA-HT-7902	LGG	TCGA	IPTPAQS	DEG_SCF_FBW7_1	0.3056
p.T4653K	DO13096	GBM	ICGC	IPTPAQS	DEG_SCF_FBW7_1	0.3056
p.T4653K	DO22518	LGG	ICGC	IPTPAQS	DEG_SCF_FBW7_1	0.3056
p.A4662T	TCGA-B5-A11E	UCEC	TCGA	IPTPAQS	DEG_SCF_FBW7_1	0.0556
p.A4662T	DO41644	UCEC	ICGC	IPTPAQS	DEG_SCF_FBW7_1	0.0556
p.I4646V	TCGA-B5-A3FA	UCEC	TCGA	IPTPAQS	DEG_SCF_FBW7_1	0.5965
p.I4646V	DO52402	UCEC	ICGC	IPTPAQS	DEG_SCF_FBW7_1	0.5965
p.F4645V	TCGA-CA-6717	COAD	TCGA	IPTPAQS	DEG_SCF_FBW7_1	0.3056
p.F4645V	DO8264	COAD	ICGC	IPTPAQS	DEG_SCF_FBW7_1	0.3056
p.M4636I	TCGA-D3-A8GC	SKCM	TCGA	IPTPAQS	DEG_SCF_FBW7_1	0.0556
p.M4636I	DO50281	SKCM	ICGC	IPTPAQS	DEG_SCF_FBW7_1	0.0556
p.P4647S	TCGA-EB-A3XB	SKCM	TCGA	IPTPAQS	DEG_SCF_FBW7_1	0.5641
p.P4647S	DO37856	SKCM	ICGC	IPTPAQS	DEG_SCF_FBW7_1	0.5641
p.S4640Y	TCGA-GN-A266	SKCM	TCGA	IPTPAQS	DEG_SCF_FBW7_1	0.1667
p.S4640Y	DO37432	SKCM	ICGC	IPTPAQS	DEG_SCF_FBW7_1	0.1667
p.V4638A	ACH-000455	Brain Cancer	CCLE	IPTPAQS	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_SCF_FBW7_1	4646:4652	IPTPAQS	FBXW7	0.9763	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons