DegronMD

Uniprot ID: Q9H3C7

Source protein: Gametogenetin-binding protein 2

Source gene: GGNBP2

Class: DEG_SCF_FBW7_1

Location: 389:395

E3 ligase: FBXW7

DEGRON score: 0.7267

ASA_SCORE: 99.9286

COIL: 0.894

CONS_SCORE: 0.3096

DSS_SCORE: 0.4223

HELIX: 0.0879

FCONS_SCORE: 0.6607

RIG_SCORE: 0.7482

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E404D	TCGA-19-5956	GBM	TCGA	IPTPLQT	DEG_SCF_FBW7_1	0.0833
p.E404D	DO13863	GBM	ICGC	IPTPLQT	DEG_SCF_FBW7_1	0.0833
p.N383S	TCGA-AP-A051	UCEC	TCGA	IPTPLQT	DEG_SCF_FBW7_1	0.1667
p.N383S	DO42673	UCEC	ICGC	IPTPLQT	DEG_SCF_FBW7_1	0.1667
p.R381Q	TCGA-F5-6814	READ	TCGA	IPTPLQT	DEG_SCF_FBW7_1	0.1111
p.R381Q	DO36556	READ	ICGC	IPTPLQT	DEG_SCF_FBW7_1	0.1111
p.E404K	TCGA-GV-A3JZ	BLCA	TCGA	IPTPLQT	DEG_SCF_FBW7_1	0.0833
p.E404K	DO773	BLCA	ICGC	IPTPLQT	DEG_SCF_FBW7_1	0.0833
p.R380K	TCGA-NC-A5HL	LUSC	TCGA	IPTPLQT	DEG_SCF_FBW7_1	0.0833
p.R380K	DO219193	LUSC	ICGC	IPTPLQT	DEG_SCF_FBW7_1	0.0833
p.V386M	DO228935	COCA	ICGC	IPTPLQT	DEG_SCF_FBW7_1	0.25
p.I389F	DO231902	LINC	ICGC	IPTPLQT	DEG_SCF_FBW7_1	0.7415
p.P392S	DO220907	MELA	ICGC	IPTPLQT	DEG_SCF_FBW7_1	0.6752
p.E398K	SIDM00150	Colorectal Carcinoma	GDSC	IPTPLQT	DEG_SCF_FBW7_1	0.25
p.E398K	ACH-000969	Colon/Colorectal Cancer	CCLE	IPTPLQT	DEG_SCF_FBW7_1	0.25
p.C385Y	SIDM01608	Endometrial Carcinoma	GDSC	IPTPLQT	DEG_SCF_FBW7_1	0.2222
p.C385Y	ACH-000990	Endometrial/Uterine Cancer	CCLE	IPTPLQT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H3C7	Gametogenetin-binding protein 2	DEG_SCF_FBW7_1	389:395	IPTPLQT	FBXW7	0.7267	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons