DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SCF_FBW7_1

Location: 10921:10927

E3 ligase: FBXW7

DEGRON score: 0.8744

ASA_SCORE: 89.5286

COIL: 0.9351

CONS_SCORE: 0

DSS_SCORE: 0.5707

HELIX: 0.0066

FCONS_SCORE: 0

RIG_SCORE: 0.6484

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T10911N	TCGA-05-4398	LUAD	TCGA	IPTPTVS	DEG_SCF_FBW7_1	0.0556
p.T10911N	DO25847	LUAD	ICGC	IPTPTVS	DEG_SCF_FBW7_1	0.0556
p.L10937V	TCGA-4Z-AA80	BLCA	TCGA	IPTPTVS	DEG_SCF_FBW7_1	0.0556
p.L10937V	TCGA-66-2785	LUSC	TCGA	IPTPTVS	DEG_SCF_FBW7_1	0.0556
p.L10937V	TCGA-E7-A6MD	BLCA	TCGA	IPTPTVS	DEG_SCF_FBW7_1	0.0556
p.L10937V	DO218986	BLCA	ICGC	IPTPTVS	DEG_SCF_FBW7_1	0.0556
p.L10937V	DO219015	BLCA	ICGC	IPTPTVS	DEG_SCF_FBW7_1	0.0556
p.L10937V	DO26520	LUSC	ICGC	IPTPTVS	DEG_SCF_FBW7_1	0.0556
p.T10911I	TCGA-66-2771	LUSC	TCGA	IPTPTVS	DEG_SCF_FBW7_1	0.0556
p.T10911I	DO26870	LUSC	ICGC	IPTPTVS	DEG_SCF_FBW7_1	0.0556
p.S10919Y	TCGA-AG-A002	READ	TCGA	IPTPTVS	DEG_SCF_FBW7_1	0.2778
p.S10919Y	DO234395	ESAD	ICGC	IPTPTVS	DEG_SCF_FBW7_1	0.2778
p.G10929E	TCGA-D3-A3C7	SKCM	TCGA	IPTPTVS	DEG_SCF_FBW7_1	0.2778
p.G10929E	DO47569	SKCM	ICGC	IPTPTVS	DEG_SCF_FBW7_1	0.2778
p.E10915K	TCGA-D3-A8GV	SKCM	TCGA	IPTPTVS	DEG_SCF_FBW7_1	0.1667
p.E10915K	DO219477	SKCM	ICGC	IPTPTVS	DEG_SCF_FBW7_1	0.1667
p.P10922S	TCGA-D9-A4Z3	SKCM	TCGA	IPTPTVS	DEG_SCF_FBW7_1	0.5641
p.P10922S	DO47555	SKCM	ICGC	IPTPTVS	DEG_SCF_FBW7_1	0.5641
p.G10932E	TCGA-EB-A42Z	SKCM	TCGA	IPTPTVS	DEG_SCF_FBW7_1	0.1944
p.G10932E	DO37414	SKCM	ICGC	IPTPTVS	DEG_SCF_FBW7_1	0.1944
p.V10926L	TCGA-EE-A29P	SKCM	TCGA	IPTPTVS	DEG_SCF_FBW7_1	0.5654
p.V10926L	DO37916	SKCM	ICGC	IPTPTVS	DEG_SCF_FBW7_1	0.5654
p.G10929W	TCGA-EE-A3AD	SKCM	TCGA	IPTPTVS	DEG_SCF_FBW7_1	0.2778
p.G10929W	DO37707	SKCM	ICGC	IPTPTVS	DEG_SCF_FBW7_1	0.2778
p.S10919F	TCGA-GN-A4U8	SKCM	TCGA	IPTPTVS	DEG_SCF_FBW7_1	0.2778
p.S10919F	DO47320	SKCM	ICGC	IPTPTVS	DEG_SCF_FBW7_1	0.2778
p.S10919F	SIDM00249	Esophageal Squamous Cell Carcinoma	GDSC	IPTPTVS	DEG_SCF_FBW7_1	0.2778
p.S10919F	ACH-000353	Esophageal Cancer	CCLE	IPTPTVS	DEG_SCF_FBW7_1	0.2778
p.S10919F	TE-15	oesophagus	COSMIC	IPTPTVS	DEG_SCF_FBW7_1	0.2778
p.S10912R	DO227999	COCA	ICGC	IPTPTVS	DEG_SCF_FBW7_1	0.0833
p.S10912R	DO229003	COCA	ICGC	IPTPTVS	DEG_SCF_FBW7_1	0.0833
p.S10912R	DO229489	LAML	ICGC	IPTPTVS	DEG_SCF_FBW7_1	0.0833
p.S10912R	DO229505	LAML	ICGC	IPTPTVS	DEG_SCF_FBW7_1	0.0833
p.E10915A	DO228899	LICA	ICGC	IPTPTVS	DEG_SCF_FBW7_1	0.1667
p.P10922T	DO228976	LICA	ICGC	IPTPTVS	DEG_SCF_FBW7_1	0.5919
p.I10921L	DO232020	LICA	ICGC	IPTPTVS	DEG_SCF_FBW7_1	0.6063
p.V10933G	DO220855	MELA	ICGC	IPTPTVS	DEG_SCF_FBW7_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IPTPTVS

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of IPTPTVS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WXI7	Mucin-16	DEG_SCF_FBW7_1	10921:10927	IPTPTVS	FBXW7	0.8744	More...