DegronMD

Uniprot ID: Q6UVY6

Source protein: DBH-like monooxygenase protein 1

Source gene: MOXD1

Class: LIG_APCC_ABBA_1

Location: 210:215

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8278

ASA_SCORE: 78.4

COIL: 0.7292

CONS_SCORE: 0.5584

DSS_SCORE: 0.0658

HELIX: 0.0645

FCONS_SCORE: 0.8184

RIG_SCORE: 0.8665

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q206K	TCGA-64-1676	LUAD	TCGA	IPVFQE	LIG_APCC_ABBA_1	0.2222
p.Q206K	DO23629	LUAD	ICGC	IPVFQE	LIG_APCC_ABBA_1	0.2222
p.V225A	TCGA-AP-A056	UCEC	TCGA	IPVFQE	LIG_APCC_ABBA_1	0.0556
p.K216N	TCGA-AX-A1CE	UCEC	TCGA	IPVFQE	LIG_APCC_ABBA_1	0.3056
p.K216N	DO42280	UCEC	ICGC	IPVFQE	LIG_APCC_ABBA_1	0.3056
p.P211L	TCGA-W3-AA1R	SKCM	TCGA	IPVFQE	LIG_APCC_ABBA_1	0.6471
p.P211L	DO51275	SKCM	ICGC	IPVFQE	LIG_APCC_ABBA_1	0.6471
p.P211L	ACH-001403	Ovarian Cancer	CCLE	IPVFQE	LIG_APCC_ABBA_1	0.6471
p.K216E	DO233828	GACA	ICGC	IPVFQE	LIG_APCC_ABBA_1	0.3056
p.P224Q	DO229025	LICA	ICGC	IPVFQE	LIG_APCC_ABBA_1	0.0833
p.T200N	DO229031	LICA	ICGC	IPVFQE	LIG_APCC_ABBA_1	0.0556
p.G211C	DO44990	LIHC	ICGC	IPVFQE	LIG_APCC_ABBA_1	0.76
p.P218S	DO220298	SARC	ICGC	IPVFQE	LIG_APCC_ABBA_1	0.25
p.I220V	SIDM00338	Acute Myeloid Leukemia	GDSC	IPVFQE	LIG_APCC_ABBA_1	0.1944
p.I220V	ACH-000439	Leukemia	CCLE	IPVFQE	LIG_APCC_ABBA_1	0.1944
p.I220V	ME-1	haematopoietic_and_lymphoid_tissue	COSMIC	IPVFQE	LIG_APCC_ABBA_1	0.1944
p.P218A	MPP-89	pleura	COSMIC	IPVFQE	LIG_APCC_ABBA_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UVY6	DBH-like monooxygenase protein 1	LIG_APCC_ABBA_1	210:215	IPVFQE	APC,CDC20,FZR1	0.8278	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons