DegronMD - Q6UVY6(MOXD1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q206K	TCGA-64-1676	LUAD	TCGA	IPVFQE	LIG_APCC_ABBA_1	210:215	Mutation rewiring degron network	0.2222
p.Q206K	TCGA-64-1676	LUAD	TCGA	KIPVFQE	LIG_APCC_ABBAyCdc20_2	209:215	Mutation rewiring degron network	0.25
p.Q206K	DO23629	LUAD	ICGC	IPVFQE	LIG_APCC_ABBA_1	210:215	Mutation rewiring degron network	0.2222
p.Q206K	DO23629	LUAD	ICGC	KIPVFQE	LIG_APCC_ABBAyCdc20_2	209:215	Mutation rewiring degron network	0.25
p.V225A	TCGA-AP-A056	UCEC	TCGA	IPVFQE	LIG_APCC_ABBA_1	210:215	Mutation rewiring degron network	0.0556
p.V225A	TCGA-AP-A056	UCEC	TCGA	KIPVFQE	LIG_APCC_ABBAyCdc20_2	209:215	Mutation rewiring degron network	0.0556
p.K216N	TCGA-AX-A1CE	UCEC	TCGA	IPVFQE	LIG_APCC_ABBA_1	210:215	Mutation rewiring degron network	0.3056
p.K216N	TCGA-AX-A1CE	UCEC	TCGA	KIPVFQE	LIG_APCC_ABBAyCdc20_2	209:215	Mutation rewiring degron network	0.3056
p.K216N	DO42280	UCEC	ICGC	IPVFQE	LIG_APCC_ABBA_1	210:215	Mutation rewiring degron network	0.3056
p.K216N	DO42280	UCEC	ICGC	KIPVFQE	LIG_APCC_ABBAyCdc20_2	209:215	Mutation rewiring degron network	0.3056
p.K209N	TCGA-B5-A1MR	UCEC	TCGA	KIPVFQE	LIG_APCC_ABBAyCdc20_2	209:215	Mutation altering degron motif	0.6918
p.K209N	DO41758	UCEC	ICGC	KIPVFQE	LIG_APCC_ABBAyCdc20_2	209:215	Mutation altering degron motif	0.6918
p.P211L	TCGA-W3-AA1R	SKCM	TCGA	IPVFQE	LIG_APCC_ABBA_1	210:215	Mutation altering degron motif	0.6471
p.P211L	TCGA-W3-AA1R	SKCM	TCGA	KIPVFQE	LIG_APCC_ABBAyCdc20_2	209:215	Mutation altering degron motif	0.6471
p.P211L	DO51275	SKCM	ICGC	IPVFQE	LIG_APCC_ABBA_1	210:215	Mutation altering degron motif	0.6471
p.P211L	DO51275	SKCM	ICGC	KIPVFQE	LIG_APCC_ABBAyCdc20_2	209:215	Mutation altering degron motif	0.6471
p.P211L	ACH-001403	Ovarian Cancer	CCLE	IPVFQE	LIG_APCC_ABBA_1	210:215	Mutation altering degron motif	0.6471
p.P211L	ACH-001403	Ovarian Cancer	CCLE	KIPVFQE	LIG_APCC_ABBAyCdc20_2	209:215	Mutation altering degron motif	0.6471
p.K216E	DO233828	GACA	ICGC	IPVFQE	LIG_APCC_ABBA_1	210:215	Mutation rewiring degron network	0.3056
p.K216E	DO233828	GACA	ICGC	KIPVFQE	LIG_APCC_ABBAyCdc20_2	209:215	Mutation rewiring degron network	0.3056
p.P224Q	DO229025	LICA	ICGC	IPVFQE	LIG_APCC_ABBA_1	210:215	Mutation rewiring degron network	0.0833
p.P224Q	DO229025	LICA	ICGC	KIPVFQE	LIG_APCC_ABBAyCdc20_2	209:215	Mutation rewiring degron network	0.0833
p.T200N	DO229031	LICA	ICGC	IPVFQE	LIG_APCC_ABBA_1	210:215	Mutation rewiring degron network	0.0556
p.T200N	DO229031	LICA	ICGC	KIPVFQE	LIG_APCC_ABBAyCdc20_2	209:215	Mutation rewiring degron network	0.0833
p.G211C	DO44990	LIHC	ICGC	IPVFQE	LIG_APCC_ABBA_1	210:215	Mutation altering degron motif	0.76
p.G211C	DO44990	LIHC	ICGC	KIPVFQE	LIG_APCC_ABBAyCdc20_2	209:215	Mutation altering degron motif	0.76
p.P218S	DO220298	SARC	ICGC	IPVFQE	LIG_APCC_ABBA_1	210:215	Mutation rewiring degron network	0.25
p.P218S	DO220298	SARC	ICGC	KIPVFQE	LIG_APCC_ABBAyCdc20_2	209:215	Mutation rewiring degron network	0.25
p.I220V	SIDM00338	Acute Myeloid Leukemia	GDSC	IPVFQE	LIG_APCC_ABBA_1	210:215	Mutation rewiring degron network	0.1944
p.I220V	SIDM00338	Acute Myeloid Leukemia	GDSC	KIPVFQE	LIG_APCC_ABBAyCdc20_2	209:215	Mutation rewiring degron network	0.1944
p.I220V	ACH-000439	Leukemia	CCLE	IPVFQE	LIG_APCC_ABBA_1	210:215	Mutation rewiring degron network	0.1944
p.I220V	ACH-000439	Leukemia	CCLE	KIPVFQE	LIG_APCC_ABBAyCdc20_2	209:215	Mutation rewiring degron network	0.1944
p.I220V	ME-1	haematopoietic and lymphoid tissue	COSMIC	IPVFQE	LIG_APCC_ABBA_1	210:215	Mutation rewiring degron network	0.1944
p.I220V	ME-1	haematopoietic and lymphoid tissue	COSMIC	KIPVFQE	LIG_APCC_ABBAyCdc20_2	209:215	Mutation rewiring degron network	0.1944
p.P218A	MPP-89	pleura	COSMIC	IPVFQE	LIG_APCC_ABBA_1	210:215	Mutation rewiring degron network	0.25
p.P218A	MPP-89	pleura	COSMIC	KIPVFQE	LIG_APCC_ABBAyCdc20_2	209:215	Mutation rewiring degron network	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MOXD1

UniProt ID: Q6UVY6

Entrez ID: 26002

Protein name: DBH-like monooxygenase protein 1 (EC 1.14.17.-) (Monooxygenase X)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MOXD1 in