DegronMD

Uniprot ID: Q6UVY6

Source protein: DBH-like monooxygenase protein 1

Source gene: MOXD1

Class: LIG_APCC_ABBAyCdc20_2

Location: 209:215

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7544

ASA_SCORE: 80.8

COIL: 0.67

CONS_SCORE: 0.5667

DSS_SCORE: 0.0706

HELIX: 0.0564

FCONS_SCORE: 0.8326

RIG_SCORE: 0.875

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q206K	TCGA-64-1676	LUAD	TCGA	KIPVFQE	LIG_APCC_ABBAyCdc20_2	0.25
p.Q206K	DO23629	LUAD	ICGC	KIPVFQE	LIG_APCC_ABBAyCdc20_2	0.25
p.V225A	TCGA-AP-A056	UCEC	TCGA	KIPVFQE	LIG_APCC_ABBAyCdc20_2	0.0556
p.K216N	TCGA-AX-A1CE	UCEC	TCGA	KIPVFQE	LIG_APCC_ABBAyCdc20_2	0.3056
p.K216N	DO42280	UCEC	ICGC	KIPVFQE	LIG_APCC_ABBAyCdc20_2	0.3056
p.K209N	TCGA-B5-A1MR	UCEC	TCGA	KIPVFQE	LIG_APCC_ABBAyCdc20_2	0.6918
p.K209N	DO41758	UCEC	ICGC	KIPVFQE	LIG_APCC_ABBAyCdc20_2	0.6918
p.P211L	TCGA-W3-AA1R	SKCM	TCGA	KIPVFQE	LIG_APCC_ABBAyCdc20_2	0.6471
p.P211L	DO51275	SKCM	ICGC	KIPVFQE	LIG_APCC_ABBAyCdc20_2	0.6471
p.P211L	ACH-001403	Ovarian Cancer	CCLE	KIPVFQE	LIG_APCC_ABBAyCdc20_2	0.6471
p.K216E	DO233828	GACA	ICGC	KIPVFQE	LIG_APCC_ABBAyCdc20_2	0.3056
p.P224Q	DO229025	LICA	ICGC	KIPVFQE	LIG_APCC_ABBAyCdc20_2	0.0833
p.T200N	DO229031	LICA	ICGC	KIPVFQE	LIG_APCC_ABBAyCdc20_2	0.0833
p.G211C	DO44990	LIHC	ICGC	KIPVFQE	LIG_APCC_ABBAyCdc20_2	0.76
p.P218S	DO220298	SARC	ICGC	KIPVFQE	LIG_APCC_ABBAyCdc20_2	0.25
p.I220V	SIDM00338	Acute Myeloid Leukemia	GDSC	KIPVFQE	LIG_APCC_ABBAyCdc20_2	0.1944
p.I220V	ACH-000439	Leukemia	CCLE	KIPVFQE	LIG_APCC_ABBAyCdc20_2	0.1944
p.I220V	ME-1	haematopoietic_and_lymphoid_tissue	COSMIC	KIPVFQE	LIG_APCC_ABBAyCdc20_2	0.1944
p.P218A	MPP-89	pleura	COSMIC	KIPVFQE	LIG_APCC_ABBAyCdc20_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UVY6	DBH-like monooxygenase protein 1	LIG_APCC_ABBAyCdc20_2	209:215	KIPVFQE	APC,CDC20,FZR1	0.7544	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons