DegronMD

Uniprot ID: Q56UN5

Source protein: Mitogen-activated protein kinase kinase kinase 19

Source gene: MAP3K19

Class: LIG_APCC_ABBA_1

Location: 520:525

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9939

ASA_SCORE: 77.5667

COIL: 0.7072

CONS_SCORE: 0.3815

DSS_SCORE: 0.7474

HELIX: 0.0758

FCONS_SCORE: 1.142

RIG_SCORE: 0.6806

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I520T	TCGA-22-5473	LUSC	TCGA	IPVHQE	LIG_APCC_ABBA_1	0.7078
p.G510R	TCGA-44-5644	LUAD	TCGA	IPVHQE	LIG_APCC_ABBA_1	0.0556
p.S517C	TCGA-49-AAR2	LUAD	TCGA	IPVHQE	LIG_APCC_ABBA_1	0.25
p.Q524K	TCGA-56-7222	LUSC	TCGA	IPVHQE	LIG_APCC_ABBA_1	0.5833
p.N515I	TCGA-77-7337	LUSC	TCGA	IPVHQE	LIG_APCC_ABBA_1	0.1944
p.K530N	TCGA-BS-A0UV	UCEC	TCGA	IPVHQE	LIG_APCC_ABBA_1	0.6389
p.P521L	DO227745	COCA	ICGC	IPVHQE	LIG_APCC_ABBA_1	0.6471
p.P521L	DO38217	STAD	ICGC	IPVHQE	LIG_APCC_ABBA_1	0.6471
p.S518C	DO44439	HNSC	ICGC	IPVHQE	LIG_APCC_ABBA_1	0.2778
p.L526I	DO229035	LICA	ICGC	IPVHQE	LIG_APCC_ABBA_1	0.3056
p.S513L	DO220908	MELA	ICGC	IPVHQE	LIG_APCC_ABBA_1	0.1389
p.S513A	DO43306	UCEC	ICGC	IPVHQE	LIG_APCC_ABBA_1	0.1389
p.P516H	DO41999	UCEC	ICGC	IPVHQE	LIG_APCC_ABBA_1	0.2222
p.C514R	DO42673	UCEC	ICGC	IPVHQE	LIG_APCC_ABBA_1	0.1667
p.Q511H	DO43971	UCEC	ICGC	IPVHQE	LIG_APCC_ABBA_1	0.0833
p.R535K	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	IPVHQE	LIG_APCC_ABBA_1	0.0556
p.R535K	ACH-002272	Lymphoma	CCLE	IPVHQE	LIG_APCC_ABBA_1	0.0556
p.R535K	MHH-PREB-1	haematopoietic_and_lymphoid_tissue	COSMIC	IPVHQE	LIG_APCC_ABBA_1	0.0556
p.R535M	SIDM00837	Colorectal Carcinoma	GDSC	IPVHQE	LIG_APCC_ABBA_1	0.0556
p.R535M	ACH-000958	Colon/Colorectal Cancer	CCLE	IPVHQE	LIG_APCC_ABBA_1	0.0556
p.R535M	SW48	large_intestine	COSMIC	IPVHQE	LIG_APCC_ABBA_1	0.0556
p.L517F	RERF-LC-KJ	lung	COSMIC	IPVHQE	LIG_APCC_ABBA_1	0.25
p.E523G	YT	haematopoietic_and_lymphoid_tissue	COSMIC	IPVHQE	LIG_APCC_ABBA_1	0.7199

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q56UN5	Mitogen-activated protein kinase kinase kinase 19	LIG_APCC_ABBA_1	520:525	IPVHQE	APC,CDC20,FZR1	0.9939	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons