DegronMD - Q56UN5(MAP3K19)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I520T	TCGA-22-5473	LUSC	TCGA	IPVHQE	LIG_APCC_ABBA_1	520:525	Mutation altering degron motif	0.7078
p.G510R	TCGA-44-5644	LUAD	TCGA	IPVHQE	LIG_APCC_ABBA_1	520:525	Mutation rewiring degron network	0.0556
p.S517C	TCGA-49-AAR2	LUAD	TCGA	IPVHQE	LIG_APCC_ABBA_1	520:525	Mutation rewiring degron network	0.25
p.Q524K	TCGA-56-7222	LUSC	TCGA	IPVHQE	LIG_APCC_ABBA_1	520:525	Mutation altering degron motif	0.5833
p.N515I	TCGA-77-7337	LUSC	TCGA	IPVHQE	LIG_APCC_ABBA_1	520:525	Mutation rewiring degron network	0.1944
p.Q798H	TCGA-BB-4227	HNSC	TCGA	LAQTPEQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.25
p.Q798H	TCGA-IQ-A61I	HNSC	TCGA	LAQTPEQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.25
p.H784Y	TCGA-BF-A3DM	SKCM	TCGA	LAQTPEQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.2222
p.I783F	TCGA-BF-A3DM	SKCM	TCGA	LAQTPEQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.1944
p.K530N	TCGA-BS-A0UV	UCEC	TCGA	IPVHQE	LIG_APCC_ABBA_1	520:525	Mutation blocking ubiquitination signal	0.6389
p.P802L	TCGA-CR-7370	HNSC	TCGA	LAQTPEQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.1389
p.P802L	SIDM01175	Other Sarcomas	GDSC	LAQTPEQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.1389
p.P802L	ACH-002309	Sarcoma	CCLE	LAQTPEQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.1389
p.P802L	SW684	soft tissue	COSMIC	LAQTPEQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.1389
p.E793V	TCGA-DU-6392	LGG	TCGA	LAQTPEQS	DEG_SCF_FBW7_1	788:795	Mutation altering degron motif	0.6582
p.M796I	TCGA-EE-A2MG	SKCM	TCGA	LAQTPEQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.3056
p.S805L	TCGA-MN-A4N4	LUAD	TCGA	LAQTPEQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.0556
p.Q790H	TCGA-P4-A5EB	KIRP	TCGA	LAQTPEQS	DEG_SCF_FBW7_1	788:795	Mutation altering degron motif	0.647
p.P521L	DO227745	COCA	ICGC	IPVHQE	LIG_APCC_ABBA_1	520:525	Mutation altering degron motif	0.6471
p.P521L	DO38217	STAD	ICGC	IPVHQE	LIG_APCC_ABBA_1	520:525	Mutation altering degron motif	0.6471
p.S518C	DO44439	HNSC	ICGC	IPVHQE	LIG_APCC_ABBA_1	520:525	Mutation rewiring degron network	0.2778
p.L526I	DO229035	LICA	ICGC	IPVHQE	LIG_APCC_ABBA_1	520:525	Mutation rewiring degron network	0.3056
p.S794Y	DO24441	LUAD	ICGC	LAQTPEQS	DEG_SCF_FBW7_1	788:795	Mutation altering degron motif	0.712
p.Q805K	DO26454	LUSC	ICGC	LAQTPEQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.0556
p.Q805K	DO37423	SKCM	ICGC	LAQTPEQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.0556
p.T791A	DO45452	LUSC	ICGC	LAQTPEQS	DEG_SCF_FBW7_1	788:795	Mutation altering degron motif	0.7139
p.A797V	DO27636	LUSC	ICGC	LAQTPEQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.2778
p.S513L	DO220908	MELA	ICGC	IPVHQE	LIG_APCC_ABBA_1	520:525	Mutation rewiring degron network	0.1389
p.D785N	DO36556	READ	ICGC	LAQTPEQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.25
p.S804F	DO47282	SKCM	ICGC	LAQTPEQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.0833
p.S513A	DO43306	UCEC	ICGC	IPVHQE	LIG_APCC_ABBA_1	520:525	Mutation rewiring degron network	0.1389
p.P516H	DO41999	UCEC	ICGC	IPVHQE	LIG_APCC_ABBA_1	520:525	Mutation rewiring degron network	0.2222
p.C514R	DO42673	UCEC	ICGC	IPVHQE	LIG_APCC_ABBA_1	520:525	Mutation rewiring degron network	0.1667
p.Q511H	DO43971	UCEC	ICGC	IPVHQE	LIG_APCC_ABBA_1	520:525	Mutation rewiring degron network	0.0833
p.R535K	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	IPVHQE	LIG_APCC_ABBA_1	520:525	Mutation rewiring degron network	0.0556
p.R535K	ACH-002272	Lymphoma	CCLE	IPVHQE	LIG_APCC_ABBA_1	520:525	Mutation rewiring degron network	0.0556
p.R535K	MHH-PREB-1	haematopoietic and lymphoid tissue	COSMIC	IPVHQE	LIG_APCC_ABBA_1	520:525	Mutation rewiring degron network	0.0556
p.P785S	SIDM00007	Other Solid Cancers	GDSC	LAQTPEQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.25
p.P785S	SIDM00796	Head and Neck Carcinoma	GDSC	LAQTPEQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.25
p.R535M	SIDM00837	Colorectal Carcinoma	GDSC	IPVHQE	LIG_APCC_ABBA_1	520:525	Mutation rewiring degron network	0.0556
p.R535M	ACH-000958	Colon/Colorectal Cancer	CCLE	IPVHQE	LIG_APCC_ABBA_1	520:525	Mutation rewiring degron network	0.0556
p.R535M	SW48	large intestine	COSMIC	IPVHQE	LIG_APCC_ABBA_1	520:525	Mutation rewiring degron network	0.0556
p.H784N	SIDM00008	Ovarian Carcinoma	GDSC	LAQTPEQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.2222
p.H784N	ACH-000796	Ovarian Cancer	CCLE	LAQTPEQS	DEG_SCF_FBW7_1	788:795	Mutation rewiring degron network	0.2222
p.L517F	RERF-LC-KJ	lung	COSMIC	IPVHQE	LIG_APCC_ABBA_1	520:525	Mutation rewiring degron network	0.25
p.E523G	YT	haematopoietic and lymphoid tissue	COSMIC	IPVHQE	LIG_APCC_ABBA_1	520:525	Mutation altering degron motif	0.7199

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAP3K19

UniProt ID: Q56UN5

Entrez ID: 80122

Protein name: Mitogen-activated protein kinase kinase kinase 19 (EC 2.7.11.1) (Regulated in COPD, protein kinase) (SPS1/STE20-related protein kinase YSK4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAP3K19 in