DegronMD

Uniprot ID: Q56UN5

Source protein: Mitogen-activated protein kinase kinase kinase 19

Source gene: MAP3K19

Class: DEG_SCF_FBW7_1

Location: 788:795

E3 ligase: FBXW7

DEGRON score: 0.9646

ASA_SCORE: 81.5625

COIL: 0.6674

CONS_SCORE: 0.3235

DSS_SCORE: 0.6898

HELIX: 0.3096

FCONS_SCORE: 1.0619

RIG_SCORE: 0.6747

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q798H	TCGA-BB-4227	HNSC	TCGA	LAQTPEQS	DEG_SCF_FBW7_1	0.25
p.Q798H	TCGA-IQ-A61I	HNSC	TCGA	LAQTPEQS	DEG_SCF_FBW7_1	0.25
p.H784Y	TCGA-BF-A3DM	SKCM	TCGA	LAQTPEQS	DEG_SCF_FBW7_1	0.2222
p.I783F	TCGA-BF-A3DM	SKCM	TCGA	LAQTPEQS	DEG_SCF_FBW7_1	0.1944
p.P802L	TCGA-CR-7370	HNSC	TCGA	LAQTPEQS	DEG_SCF_FBW7_1	0.1389
p.P802L	SIDM01175	Other Sarcomas	GDSC	LAQTPEQS	DEG_SCF_FBW7_1	0.1389
p.P802L	ACH-002309	Sarcoma	CCLE	LAQTPEQS	DEG_SCF_FBW7_1	0.1389
p.P802L	SW684	soft_tissue	COSMIC	LAQTPEQS	DEG_SCF_FBW7_1	0.1389
p.E793V	TCGA-DU-6392	LGG	TCGA	LAQTPEQS	DEG_SCF_FBW7_1	0.6582
p.M796I	TCGA-EE-A2MG	SKCM	TCGA	LAQTPEQS	DEG_SCF_FBW7_1	0.3056
p.S805L	TCGA-MN-A4N4	LUAD	TCGA	LAQTPEQS	DEG_SCF_FBW7_1	0.0556
p.Q790H	TCGA-P4-A5EB	KIRP	TCGA	LAQTPEQS	DEG_SCF_FBW7_1	0.647
p.S794Y	DO24441	LUAD	ICGC	LAQTPEQS	DEG_SCF_FBW7_1	0.712
p.Q805K	DO26454	LUSC	ICGC	LAQTPEQS	DEG_SCF_FBW7_1	0.0556
p.Q805K	DO37423	SKCM	ICGC	LAQTPEQS	DEG_SCF_FBW7_1	0.0556
p.T791A	DO45452	LUSC	ICGC	LAQTPEQS	DEG_SCF_FBW7_1	0.7139
p.A797V	DO27636	LUSC	ICGC	LAQTPEQS	DEG_SCF_FBW7_1	0.2778
p.D785N	DO36556	READ	ICGC	LAQTPEQS	DEG_SCF_FBW7_1	0.25
p.S804F	DO47282	SKCM	ICGC	LAQTPEQS	DEG_SCF_FBW7_1	0.0833
p.P785S	SIDM00007	Other Solid Cancers	GDSC	LAQTPEQS	DEG_SCF_FBW7_1	0.25
p.P785S	SIDM00796	Head and Neck Carcinoma	GDSC	LAQTPEQS	DEG_SCF_FBW7_1	0.25
p.H784N	SIDM00008	Ovarian Carcinoma	GDSC	LAQTPEQS	DEG_SCF_FBW7_1	0.2222
p.H784N	ACH-000796	Ovarian Cancer	CCLE	LAQTPEQS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q56UN5	Mitogen-activated protein kinase kinase kinase 19	DEG_SCF_FBW7_1	788:795	LAQTPEQS	FBXW7	0.9646	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons