DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
IQATWRGYRVR
Uniprot ID:
Q9H0B3
Source protein:
IQ domain-containing protein N
Source gene:
IQCN
Class:
SCF_FBXL2
Location:
956:966
E3 ligase:
FBXL2
DEGRON score:
0.7631
ASA_SCORE:
68.3364
COIL:
0.3523
CONS_SCORE:
0.6894
DSS_SCORE:
0.0661
HELIX:
0.6315
FCONS_SCORE:
1.476
RIG_SCORE:
0.9056
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R952Q
SIDM01270
Esophageal Carcinoma
GDSC
IQATWRGYRVR
SCF_FBXL2
0.2222
p.R960W
SIDM00233
T-Lymphoblastic Leukemia
GDSC
IQATWRGYRVR
SCF_FBXL2
0.8634
p.R960W
ATN-1
haematopoietic_and_lymphoid_tissue
COSMIC
IQATWRGYRVR
SCF_FBXL2
0.8634
p.R967Q
AN3-CA
endometrium
COSMIC
IQATWRGYRVR
SCF_FBXL2
0.3056
p.R966W
HT-115
large_intestine
COSMIC
IQATWRGYRVR
SCF_FBXL2
0.7523
p.R961H
NALM-6
haematopoietic_and_lymphoid_tissue
COSMIC
IQATWRGYRVR
SCF_FBXL2
0.8244
Drug responses associated with IQCN mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of IQATWRGYRVR
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9H0B3
IQ domain-containing protein N
SCF_FBXL2
956:966
IQATWRGYRVR
FBXL2
0.7631
More...
