DegronMD - Q9H0B3(IQCN)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R952Q	SIDM01270	Esophageal Carcinoma	GDSC	IQATWRGYRVR	SCF_FBXL2	956:966	Mutation rewiring degron network	0.2222
p.R960W	SIDM00233	T-Lymphoblastic Leukemia	GDSC	IQATWRGYRVR	SCF_FBXL2	956:966	Mutation altering degron motif	0.8634
p.R960W	ATN-1	haematopoietic and lymphoid tissue	COSMIC	IQATWRGYRVR	SCF_FBXL2	956:966	Mutation altering degron motif	0.8634
p.R967Q	AN3-CA	endometrium	COSMIC	IQATWRGYRVR	SCF_FBXL2	956:966	Mutation rewiring degron network	0.3056
p.R966W	HT-115	large intestine	COSMIC	IQATWRGYRVR	SCF_FBXL2	956:966	Mutation altering degron motif	0.7523
p.T355S	SNU-1040	large intestine	COSMIC	MTTTPPKT	DEG_SCF_FBW7_1	359:366	Mutation rewiring degron network	0.2222
p.R961H	NALM-6	haematopoietic and lymphoid tissue	COSMIC	IQATWRGYRVR	SCF_FBXL2	956:966	Mutation altering degron motif	0.8244

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons