DegronMD

Uniprot ID: Q14940

Source protein: Sodium/hydrogen exchanger 5

Source gene: SLC9A5

Class: SCF_FBXL2

Location: 888:895

E3 ligase: FBXL2

DEGRON score: 0.6893

ASA_SCORE: 79.3

COIL: 0.5961

CONS_SCORE: 0.2467

DSS_SCORE: 0.6036

HELIX: 0.1156

FCONS_SCORE: 0.975

RIG_SCORE: 0.7879

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W886L	TCGA-18-3414	LUSC	TCGA	IQFNRGSR	SCF_FBXL2	0.2778
p.W886L	DO26629	LUSC	ICGC	IQFNRGSR	SCF_FBXL2	0.2778
p.G880C	TCGA-A5-A1OF	UCEC	TCGA	IQFNRGSR	SCF_FBXL2	0.1111
p.G880C	DO42568	UCEC	ICGC	IQFNRGSR	SCF_FBXL2	0.1111
p.L896M	TCGA-DU-6392	LGG	TCGA	IQFNRGSR	SCF_FBXL2	0.3056
p.L896M	DO22237	LGG	ICGC	IQFNRGSR	SCF_FBXL2	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q14940	Sodium/hydrogen exchanger 5	SCF_FBXL2	888:895	IQFNRGSR	FBXL2	0.6893	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons