DegronMD

Uniprot ID: Q53HL2

Source protein: Borealin

Source gene: CDCA8

Class: DEG_SCF_FBW7_1

Location: 104:110

E3 ligase: FBXW7

DEGRON score: 0.9976

ASA_SCORE: 88.0429

COIL: 0.7244

CONS_SCORE: 0.679

DSS_SCORE: 0.2781

HELIX: 0.2079

FCONS_SCORE: 2.8111

RIG_SCORE: 0.7645

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E95K	TCGA-EO-A22U	UCEC	TCGA	IQTPLKS	DEG_SCF_FBW7_1	0.0833
p.E95K	DO222521	MELA	ICGC	IQTPLKS	DEG_SCF_FBW7_1	0.0833
p.E95K	DO43755	UCEC	ICGC	IQTPLKS	DEG_SCF_FBW7_1	0.0833
p.D120Y	TCGA-LN-A9FP	ESCA	TCGA	IQTPLKS	DEG_SCF_FBW7_1	0.0556
p.T94N	DO217896	GACA	ICGC	IQTPLKS	DEG_SCF_FBW7_1	0.5
p.Q118H	DO228985	LICA	ICGC	IQTPLKS	DEG_SCF_FBW7_1	0.1111
p.R114Q	SIDM00944	Colorectal Carcinoma	GDSC	IQTPLKS	DEG_SCF_FBW7_1	0.2222
p.R114Q	SIDM00695	Melanoma	GDSC	IQTPLKS	DEG_SCF_FBW7_1	0.2222
p.R114Q	SIDM00952	B-Cell Non-Hodgkin's Lymphoma	GDSC	IQTPLKS	DEG_SCF_FBW7_1	0.2222
p.R114Q	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	IQTPLKS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q53HL2	Borealin	DEG_SCF_FBW7_1	104:110	IQTPLKS	FBXW7	0.9976	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons