DegronMD - Q53HL2(CDCA8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G187C	TCGA-A5-A0G1	UCEC	TCGA	VKPTPGLT	DEG_SCF_FBW7_1	182:189	Mutation altering degron motif	0.6489
p.G187C	DO42472	UCEC	ICGC	VKPTPGLT	DEG_SCF_FBW7_1	182:189	Mutation altering degron motif	0.6489
p.R176Q	TCGA-AP-A0LF	UCEC	TCGA	VKPTPGLT	DEG_SCF_FBW7_1	182:189	Mutation rewiring degron network	0.1667
p.R176Q	DO43610	UCEC	ICGC	VKPTPGLT	DEG_SCF_FBW7_1	182:189	Mutation rewiring degron network	0.1667
p.E95K	TCGA-EO-A22U	UCEC	TCGA	IQTPLKS	DEG_SCF_FBW7_1	104:110	Mutation rewiring degron network	0.0833
p.E95K	DO222521	MELA	ICGC	IQTPLKS	DEG_SCF_FBW7_1	104:110	Mutation rewiring degron network	0.0833
p.E95K	DO43755	UCEC	ICGC	IQTPLKS	DEG_SCF_FBW7_1	104:110	Mutation rewiring degron network	0.0833
p.A173V	TCGA-IB-7651	PAAD	TCGA	VKPTPGLT	DEG_SCF_FBW7_1	182:189	Mutation rewiring degron network	0.0833
p.A173V	DO46657	PAAD	ICGC	VKPTPGLT	DEG_SCF_FBW7_1	182:189	Mutation rewiring degron network	0.0833
p.D120Y	TCGA-LN-A9FP	ESCA	TCGA	IQTPLKS	DEG_SCF_FBW7_1	104:110	Mutation rewiring degron network	0.0556
p.T94N	DO217896	GACA	ICGC	IQTPLKS	DEG_SCF_FBW7_1	104:110	Mutation blocking phosphorylation signal	0.5
p.R191M	DO228971	LICA	ICGC	VKPTPGLT	DEG_SCF_FBW7_1	182:189	Mutation rewiring degron network	0.2778
p.Q118H	DO228985	LICA	ICGC	IQTPLKS	DEG_SCF_FBW7_1	104:110	Mutation rewiring degron network	0.1111
p.R176L	DO229009	LICA	ICGC	VKPTPGLT	DEG_SCF_FBW7_1	182:189	Mutation rewiring degron network	0.1667
p.R114Q	SIDM00944	Colorectal Carcinoma	GDSC	IQTPLKS	DEG_SCF_FBW7_1	104:110	Mutation rewiring degron network	0.2222
p.R114Q	SIDM00695	Melanoma	GDSC	IQTPLKS	DEG_SCF_FBW7_1	104:110	Mutation rewiring degron network	0.2222
p.R114Q	SIDM00952	B-Cell Non-Hodgkin's Lymphoma	GDSC	IQTPLKS	DEG_SCF_FBW7_1	104:110	Mutation rewiring degron network	0.2222
p.R114Q	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	IQTPLKS	DEG_SCF_FBW7_1	104:110	Mutation rewiring degron network	0.2222
p.R195S	SIDM00569	Osteosarcoma	GDSC	VKPTPGLT	DEG_SCF_FBW7_1	182:189	Mutation rewiring degron network	0.1667
p.R195S	NY	bone	COSMIC	VKPTPGLT	DEG_SCF_FBW7_1	182:189	Mutation rewiring degron network	0.1667
p.V174M	SIDM00095	Glioblastoma	GDSC	VKPTPGLT	DEG_SCF_FBW7_1	182:189	Mutation rewiring degron network	0.1111
p.V174M	ACH-000504	Brain Cancer	CCLE	VKPTPGLT	DEG_SCF_FBW7_1	182:189	Mutation rewiring degron network	0.1111
p.V174M	SNB75	central nervous system	COSMIC	VKPTPGLT	DEG_SCF_FBW7_1	182:189	Mutation rewiring degron network	0.1111
p.P172L	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	VKPTPGLT	DEG_SCF_FBW7_1	182:189	Mutation rewiring degron network	0.0556
p.P172L	ACH-001642	Lymphoma	CCLE	VKPTPGLT	DEG_SCF_FBW7_1	182:189	Mutation rewiring degron network	0.0556
p.E178D	NCI-H128	lung	COSMIC	VKPTPGLT	DEG_SCF_FBW7_1	182:189	Mutation rewiring degron network	0.2222

Kaplan plot for CDCA8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CDCA8

UniProt ID: Q53HL2

Entrez ID: 55143

Protein name: Borealin (Cell division cycle-associated protein 8) (Dasra-B) (hDasra-B) (Pluripotent embryonic stem cell-related gene 3 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CDCA8 in