DegronMD

Uniprot ID: Q53HL2

Source protein: Borealin

Source gene: CDCA8

Class: DEG_SCF_FBW7_1

Location: 182:189

E3 ligase: FBXW7

DEGRON score: 0.9996

ASA_SCORE: 75.35

COIL: 0.9406

CONS_SCORE: 0.7523

DSS_SCORE: 0.4793

HELIX: 0.0165

FCONS_SCORE: 1.0314

RIG_SCORE: 0.7012

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G187C	TCGA-A5-A0G1	UCEC	TCGA	VKPTPGLT	DEG_SCF_FBW7_1	0.6489
p.G187C	DO42472	UCEC	ICGC	VKPTPGLT	DEG_SCF_FBW7_1	0.6489
p.R176Q	TCGA-AP-A0LF	UCEC	TCGA	VKPTPGLT	DEG_SCF_FBW7_1	0.1667
p.R176Q	DO43610	UCEC	ICGC	VKPTPGLT	DEG_SCF_FBW7_1	0.1667
p.A173V	TCGA-IB-7651	PAAD	TCGA	VKPTPGLT	DEG_SCF_FBW7_1	0.0833
p.A173V	DO46657	PAAD	ICGC	VKPTPGLT	DEG_SCF_FBW7_1	0.0833
p.R191M	DO228971	LICA	ICGC	VKPTPGLT	DEG_SCF_FBW7_1	0.2778
p.R176L	DO229009	LICA	ICGC	VKPTPGLT	DEG_SCF_FBW7_1	0.1667
p.R195S	SIDM00569	Osteosarcoma	GDSC	VKPTPGLT	DEG_SCF_FBW7_1	0.1667
p.R195S	NY	bone	COSMIC	VKPTPGLT	DEG_SCF_FBW7_1	0.1667
p.V174M	SIDM00095	Glioblastoma	GDSC	VKPTPGLT	DEG_SCF_FBW7_1	0.1111
p.V174M	ACH-000504	Brain Cancer	CCLE	VKPTPGLT	DEG_SCF_FBW7_1	0.1111
p.V174M	SNB75	central_nervous_system	COSMIC	VKPTPGLT	DEG_SCF_FBW7_1	0.1111
p.P172L	SIDM00384	B-Cell Non-Hodgkin's Lymphoma	GDSC	VKPTPGLT	DEG_SCF_FBW7_1	0.0556
p.P172L	ACH-001642	Lymphoma	CCLE	VKPTPGLT	DEG_SCF_FBW7_1	0.0556
p.E178D	NCI-H128	lung	COSMIC	VKPTPGLT	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q53HL2	Borealin	DEG_SCF_FBW7_1	182:189	VKPTPGLT	FBXW7	0.9996	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons