DegronMD

Uniprot ID: P32856

Source protein: Syntaxin-2

Source gene: STX2

Class: DEG_APCC_DBOX_1

Location: 88:96

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5642

ASA_SCORE: 63.2778

COIL: 0.0253

CONS_SCORE: 0.4339

DSS_SCORE: 0.3612

HELIX: 0.9761

FCONS_SCORE: 1.5027

RIG_SCORE: 0.8001

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K87T	TCGA-AG-3902	READ	TCGA	IRAKLKAIE	DEG_APCC_DBOX_1	0.3056
p.K87T	DO36407	READ	ICGC	IRAKLKAIE	DEG_APCC_DBOX_1	0.3056
p.K93N	TCGA-B5-A11E	UCEC	TCGA	IRAKLKAIE	DEG_APCC_DBOX_1	0.5806
p.K93N	DO41644	UCEC	ICGC	IRAKLKAIE	DEG_APCC_DBOX_1	0.5806
p.D100N	DO234246	ESAD	ICGC	IRAKLKAIE	DEG_APCC_DBOX_1	0.2222
p.N78K	DO228986	LICA	ICGC	IRAKLKAIE	DEG_APCC_DBOX_1	0.0556
p.I95V	SIDM00773	Non-Cancerous	GDSC	IRAKLKAIE	DEG_APCC_DBOX_1	0.5965
p.I95V	SIDM01090	Colorectal Carcinoma	GDSC	IRAKLKAIE	DEG_APCC_DBOX_1	0.5965
p.I95V	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	IRAKLKAIE	DEG_APCC_DBOX_1	0.5965
p.I95V	SIDM00654	Small Cell Lung Carcinoma	GDSC	IRAKLKAIE	DEG_APCC_DBOX_1	0.5965
p.I95V	SIDM00774	Breast Carcinoma	GDSC	IRAKLKAIE	DEG_APCC_DBOX_1	0.5965
p.I95V	SIDM00257	Neuroblastoma	GDSC	IRAKLKAIE	DEG_APCC_DBOX_1	0.5965

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P32856	Syntaxin-2	DEG_APCC_DBOX_1	88:96	IRAKLKAIE	APC,CDC20,FZR1	0.5642	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons