DegronMD - P32856(STX2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G17A	TCGA-50-5066	LUAD	TCGA	MRDRLPDLT	DEG_APCC_DBOX_1	1:9	Mutation rewiring degron network	0.1111
p.G17A	TCGA-XF-AAMG	BLCA	TCGA	MRDRLPDLT	DEG_APCC_DBOX_1	1:9	Mutation rewiring degron network	0.1111
p.G17A	DO219049	BLCA	ICGC	MRDRLPDLT	DEG_APCC_DBOX_1	1:9	Mutation rewiring degron network	0.1111
p.G17A	DO25040	LUAD	ICGC	MRDRLPDLT	DEG_APCC_DBOX_1	1:9	Mutation rewiring degron network	0.1111
p.K87T	TCGA-AG-3902	READ	TCGA	IRAKLKAIE	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.3056
p.K87T	DO36407	READ	ICGC	IRAKLKAIE	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.3056
p.K93N	TCGA-B5-A11E	UCEC	TCGA	IRAKLKAIE	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.5806
p.K93N	DO41644	UCEC	ICGC	IRAKLKAIE	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.5806
p.P6L	DO225235	BRCA	ICGC	MRDRLPDLT	DEG_APCC_DBOX_1	1:9	Mutation altering degron motif	0.6471
p.D18V	DO50354	ESAD	ICGC	MRDRLPDLT	DEG_APCC_DBOX_1	1:9	Mutation rewiring degron network	0.0833
p.D100N	DO234246	ESAD	ICGC	IRAKLKAIE	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.2222
p.N78K	DO228986	LICA	ICGC	IRAKLKAIE	DEG_APCC_DBOX_1	88:96	Mutation rewiring degron network	0.0556
p.C11F	DO229234	THCA	ICGC	MRDRLPDLT	DEG_APCC_DBOX_1	1:9	Mutation rewiring degron network	0.2778
p.I95V	SIDM00773	Non-Cancerous	GDSC	IRAKLKAIE	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.5965
p.I95V	SIDM01090	Colorectal Carcinoma	GDSC	IRAKLKAIE	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.5965
p.I95V	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	IRAKLKAIE	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.5965
p.I95V	SIDM00654	Small Cell Lung Carcinoma	GDSC	IRAKLKAIE	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.5965
p.I95V	SIDM00774	Breast Carcinoma	GDSC	IRAKLKAIE	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.5965
p.I95V	SIDM00257	Neuroblastoma	GDSC	IRAKLKAIE	DEG_APCC_DBOX_1	88:96	Mutation altering degron motif	0.5965
p.N14S	SIDM00942	Oral Cavity Carcinoma	GDSC	MRDRLPDLT	DEG_APCC_DBOX_1	1:9	Mutation rewiring degron network	0.1944
p.N14S	CAL-33	upper aerodigestive tract	COSMIC	MRDRLPDLT	DEG_APCC_DBOX_1	1:9	Mutation rewiring degron network	0.1944

Kaplan plot for STX2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

STX2

UniProt ID: P32856

Entrez ID: 2054

Protein name: Syntaxin-2 (Epimorphin)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for STX2 in