DegronMD

Uniprot ID: P32856

Source protein: Syntaxin-2

Source gene: STX2

Class: DEG_APCC_DBOX_1

Location: 1:9

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9979

ASA_SCORE: 83.3333

COIL: 0.5951

CONS_SCORE: 0.3509

DSS_SCORE: 0.6827

HELIX: 0.3917

FCONS_SCORE: 1.5142

RIG_SCORE: 0.7793

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G17A	TCGA-50-5066	LUAD	TCGA	MRDRLPDLT	DEG_APCC_DBOX_1	0.1111
p.G17A	TCGA-XF-AAMG	BLCA	TCGA	MRDRLPDLT	DEG_APCC_DBOX_1	0.1111
p.G17A	DO219049	BLCA	ICGC	MRDRLPDLT	DEG_APCC_DBOX_1	0.1111
p.G17A	DO25040	LUAD	ICGC	MRDRLPDLT	DEG_APCC_DBOX_1	0.1111
p.P6L	DO225235	BRCA	ICGC	MRDRLPDLT	DEG_APCC_DBOX_1	0.6471
p.D18V	DO50354	ESAD	ICGC	MRDRLPDLT	DEG_APCC_DBOX_1	0.0833
p.C11F	DO229234	THCA	ICGC	MRDRLPDLT	DEG_APCC_DBOX_1	0.2778
p.N14S	SIDM00942	Oral Cavity Carcinoma	GDSC	MRDRLPDLT	DEG_APCC_DBOX_1	0.1944
p.N14S	CAL-33	upper_aerodigestive_tract	COSMIC	MRDRLPDLT	DEG_APCC_DBOX_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P32856	Syntaxin-2	DEG_APCC_DBOX_1	1:9	MRDRLPDLT	APC,CDC20,FZR1	0.9979	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons