DegronMD

Uniprot ID: Q05193

Source protein: Dynamin-1

Source gene: DNM1

Class: DEG_APCC_DBOX_1

Location: 289:297

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8014

ASA_SCORE: 55.4889

COIL: 0.2118

CONS_SCORE: 0.8238

DSS_SCORE: 0.3765

HELIX: 0.7828

FCONS_SCORE: 1.0862

RIG_SCORE: 0.7856

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q283E	TCGA-LT-A5Z6	BLCA	TCGA	IRDTLPGLR	DEG_APCC_DBOX_1	0.1667
p.Q283E	DO44029	BLCA	ICGC	IRDTLPGLR	DEG_APCC_DBOX_1	0.1667
p.R297W	TCGA-QQ-A8VF	SARC	TCGA	IRDTLPGLR	DEG_APCC_DBOX_1	0.7523
p.R297W	DO220258	SARC	ICGC	IRDTLPGLR	DEG_APCC_DBOX_1	0.7523
p.R297W	DO38404	STAD	ICGC	IRDTLPGLR	DEG_APCC_DBOX_1	0.7523
p.Q283K	DO222463	BTCA	ICGC	IRDTLPGLR	DEG_APCC_DBOX_1	0.1667
p.T286M	DO222955	BTCA	ICGC	IRDTLPGLR	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q05193	Dynamin-1	DEG_APCC_DBOX_1	289:297	IRDTLPGLR	APC,CDC20,FZR1	0.8014	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons