DegronMD - Q05193(DNM1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y626F	TCGA-05-4397	LUAD	TCGA	RAGVYPE	LIG_APCC_ABBAyCdc20_2	622:628	Mutation altering degron motif	0.6417
p.Y626F	DO25320	LUAD	ICGC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	622:628	Mutation altering degron motif	0.6417
p.A623D	TCGA-06-5416	GBM	TCGA	RAGVYPE	LIG_APCC_ABBAyCdc20_2	622:628	Mutation altering degron motif	0.6682
p.A623D	DO10880	GBM	ICGC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	622:628	Mutation altering degron motif	0.6682
p.E634D	TCGA-AA-A010	COAD	TCGA	RAGVYPE	LIG_APCC_ABBAyCdc20_2	622:628	Mutation rewiring degron network	0.1667
p.E634D	TCGA-CA-6717	COAD	TCGA	RAGVYPE	LIG_APCC_ABBAyCdc20_2	622:628	Mutation rewiring degron network	0.1667
p.E634D	DO8264	COAD	ICGC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	622:628	Mutation rewiring degron network	0.1667
p.E638K	TCGA-BQ-5886	KIRP	TCGA	RAGVYPE	LIG_APCC_ABBAyCdc20_2	622:628	Mutation rewiring degron network	0.0556
p.E638K	DO20901	KIRP	ICGC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	622:628	Mutation rewiring degron network	0.0556
p.G631V	TCGA-EE-A2MD	SKCM	TCGA	RAGVYPE	LIG_APCC_ABBAyCdc20_2	622:628	Mutation rewiring degron network	0.25
p.G631V	DO37851	SKCM	ICGC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	622:628	Mutation rewiring degron network	0.25
p.R622M	TCGA-ET-A39R	THCA	TCGA	RAGVYPE	LIG_APCC_ABBAyCdc20_2	622:628	Mutation altering degron motif	0.8632
p.R622M	DO39552	THCA	ICGC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	622:628	Mutation altering degron motif	0.8632
p.S619F	TCGA-FW-A3R5	SKCM	TCGA	RAGVYPE	LIG_APCC_ABBAyCdc20_2	622:628	Mutation rewiring degron network	0.25
p.S619F	DO37406	SKCM	ICGC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	622:628	Mutation rewiring degron network	0.25
p.Q283E	TCGA-LT-A5Z6	BLCA	TCGA	IRDTLPGLR	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.1667
p.Q283E	DO44029	BLCA	ICGC	IRDTLPGLR	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.1667
p.R297W	TCGA-QQ-A8VF	SARC	TCGA	IRDTLPGLR	DEG_APCC_DBOX_1	289:297	Mutation altering degron motif	0.7523
p.R297W	DO220258	SARC	ICGC	IRDTLPGLR	DEG_APCC_DBOX_1	289:297	Mutation altering degron motif	0.7523
p.R297W	DO38404	STAD	ICGC	IRDTLPGLR	DEG_APCC_DBOX_1	289:297	Mutation altering degron motif	0.7523
p.Q283K	DO222463	BTCA	ICGC	IRDTLPGLR	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.1667
p.T286M	DO222955	BTCA	ICGC	IRDTLPGLR	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.25
p.E612D	DO229031	LICA	ICGC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	622:628	Mutation rewiring degron network	0.0556
p.R629C	ACH-001061	Colon/Colorectal Cancer	CCLE	RAGVYPE	LIG_APCC_ABBAyCdc20_2	622:628	Mutation rewiring degron network	0.3056
p.E631D	SNU-81	large intestine	COSMIC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	622:628	Mutation rewiring degron network	0.25
p.R634W	SNU-175	large intestine	COSMIC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	622:628	Mutation rewiring degron network	0.1667

Kaplan plot for DNM1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DNM1

UniProt ID: Q05193

Entrez ID: 1759

Protein name: Dynamin-1 (EC 3.6.5.5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DNM1 in