DegronMD

Uniprot ID: Q05193

Source protein: Dynamin-1

Source gene: DNM1

Class: LIG_APCC_ABBAyCdc20_2

Location: 622:628

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9707

ASA_SCORE: 74.4

COIL: 0.6711

CONS_SCORE: 0.6503

DSS_SCORE: 0.3589

HELIX: 0.1074

FCONS_SCORE: 1.4584

RIG_SCORE: 0.7585

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R622M	TCGA-ET-A39R	THCA	TCGA	RAGVYPE	LIG_APCC_ABBAyCdc20_2	0.8632
p.R622M	DO39552	THCA	ICGC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	0.8632
p.A623D	TCGA-06-5416	GBM	TCGA	RAGVYPE	LIG_APCC_ABBAyCdc20_2	0.6682
p.A623D	DO10880	GBM	ICGC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	0.6682
p.Y626F	TCGA-05-4397	LUAD	TCGA	RAGVYPE	LIG_APCC_ABBAyCdc20_2	0.6417
p.Y626F	DO25320	LUAD	ICGC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	0.6417
p.R629C	ACH-001061	Colon/Colorectal Cancer	CCLE	RAGVYPE	LIG_APCC_ABBAyCdc20_2	0.3056
p.G631V	TCGA-EE-A2MD	SKCM	TCGA	RAGVYPE	LIG_APCC_ABBAyCdc20_2	0.25
p.G631V	DO37851	SKCM	ICGC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	0.25
p.S619F	TCGA-FW-A3R5	SKCM	TCGA	RAGVYPE	LIG_APCC_ABBAyCdc20_2	0.25
p.S619F	DO37406	SKCM	ICGC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	0.25
p.E631D	SNU-81	large_intestine	COSMIC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	0.25
p.E634D	TCGA-AA-A010	COAD	TCGA	RAGVYPE	LIG_APCC_ABBAyCdc20_2	0.1667
p.E634D	TCGA-CA-6717	COAD	TCGA	RAGVYPE	LIG_APCC_ABBAyCdc20_2	0.1667
p.E634D	DO8264	COAD	ICGC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	0.1667
p.R634W	SNU-175	large_intestine	COSMIC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	0.1667
p.E638K	TCGA-BQ-5886	KIRP	TCGA	RAGVYPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.E638K	DO20901	KIRP	ICGC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.E612D	DO229031	LICA	ICGC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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DegronMD: protein-targeted degradation, mutation and drug response to degrons