DegronMD - P50570(DNM2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q283E	TCGA-62-A471	LUAD	TCGA	IRESLPALR	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.1667
p.Q283E	DO45347	LUAD	ICGC	IRESLPALR	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.1667
p.E635K	TCGA-A2-A0CX	BRCA	TCGA	RAGVYPE	LIG_APCC_ABBAyCdc20_2	622:628	Mutation rewiring degron network	0.1389
p.L296I	TCGA-A6-5661	COAD	TCGA	IRESLPALR	DEG_APCC_DBOX_1	289:297	Mutation altering degron motif	0.6063
p.L296I	TCGA-VQ-A8E3	STAD	TCGA	IRESLPALR	DEG_APCC_DBOX_1	289:297	Mutation altering degron motif	0.6063
p.L296I	DO8634	COAD	ICGC	IRESLPALR	DEG_APCC_DBOX_1	289:297	Mutation altering degron motif	0.6063
p.L296I	DO51759	STAD	ICGC	IRESLPALR	DEG_APCC_DBOX_1	289:297	Mutation altering degron motif	0.6063
p.A638T	TCGA-AG-A002	READ	TCGA	RAGVYPE	LIG_APCC_ABBAyCdc20_2	622:628	Mutation rewiring degron network	0.0556
p.T280M	TCGA-AJ-A3BH	UCEC	TCGA	IRESLPALR	DEG_APCC_DBOX_1	289:297	Mutation blocking phosphorylation signal	0.5278
p.T280M	DO41638	UCEC	ICGC	IRESLPALR	DEG_APCC_DBOX_1	289:297	Mutation blocking phosphorylation signal	0.5278
p.T280M	SIDM01686	Chronic Myelogenous Leukemia	GDSC	IRESLPALR	DEG_APCC_DBOX_1	289:297	Mutation blocking phosphorylation signal	0.5278
p.T280M	ACH-000462	Leukemia	CCLE	IRESLPALR	DEG_APCC_DBOX_1	289:297	Mutation blocking phosphorylation signal	0.5278
p.V625I	TCGA-AJ-A3BH	UCEC	TCGA	RAGVYPE	LIG_APCC_ABBAyCdc20_2	622:628	Mutation altering degron motif	0.5965
p.E291D	TCGA-E9-A1RF	BRCA	TCGA	IRESLPALR	DEG_APCC_DBOX_1	289:297	Mutation altering degron motif	0.5647
p.E291D	DO2665	BRCA	ICGC	IRESLPALR	DEG_APCC_DBOX_1	289:297	Mutation altering degron motif	0.5647
p.H288N	TCGA-EE-A29X	SKCM	TCGA	IRESLPALR	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.3056
p.H288N	DO37595	SKCM	ICGC	IRESLPALR	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.3056
p.R290W	TCGA-EO-A3AZ	UCEC	TCGA	IRESLPALR	DEG_APCC_DBOX_1	289:297	Mutation altering degron motif	0.8634
p.R290W	DO50078	UCEC	ICGC	IRESLPALR	DEG_APCC_DBOX_1	289:297	Mutation altering degron motif	0.8634
p.P627H	TCGA-FS-A1ZK	SKCM	TCGA	RAGVYPE	LIG_APCC_ABBAyCdc20_2	622:628	Mutation altering degron motif	0.6583
p.S619L	TCGA-FW-A3R5	SKCM	TCGA	RAGVYPE	LIG_APCC_ABBAyCdc20_2	622:628	Mutation rewiring degron network	0.25
p.D612N	TCGA-GV-A3JZ	BLCA	TCGA	RAGVYPE	LIG_APCC_ABBAyCdc20_2	622:628	Mutation rewiring degron network	0.0556
p.W616C	TCGA-GV-A3JZ	BLCA	TCGA	RAGVYPE	LIG_APCC_ABBAyCdc20_2	622:628	Mutation rewiring degron network	0.1667
p.S302C	TCGA-QK-A6II	HNSC	TCGA	IRESLPALR	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.1944
p.S302C	DO50006	HNSC	ICGC	IRESLPALR	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.1944
p.S298N	TCGA-XK-AAJP	PRAD	TCGA	IRESLPALR	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.3056
p.S298N	DO51410	PRAD	ICGC	IRESLPALR	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.3056
p.W612C	DO773	BLCA	ICGC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	622:628	Mutation rewiring degron network	0.0556
p.E631K	DO2755	BRCA	ICGC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	622:628	Mutation rewiring degron network	0.25
p.A295S	DO229029	LICA	ICGC	IRESLPALR	DEG_APCC_DBOX_1	289:297	Mutation altering degron motif	0.6477
p.S615L	DO221126	MALY	ICGC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	622:628	Mutation rewiring degron network	0.1389
p.S615L	DO37406	SKCM	ICGC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	622:628	Mutation rewiring degron network	0.1389
p.P623H	DO37474	SKCM	ICGC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	622:628	Mutation altering degron motif	0.7694
p.V621I	DO41638	UCEC	ICGC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	622:628	Mutation rewiring degron network	0.3056
p.R297H	DO41199	UCEC	ICGC	IRESLPALR	DEG_APCC_DBOX_1	289:297	Mutation altering degron motif	0.7133
p.Q283R	SIDM00620	Glioblastoma	GDSC	IRESLPALR	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.1667
p.Q283R	D-336MG	central nervous system	COSMIC	IRESLPALR	DEG_APCC_DBOX_1	289:297	Mutation rewiring degron network	0.1667
p.A618T	SIDM00671	T-Cell Non-Hodgkin's Lymphoma	GDSC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	622:628	Mutation rewiring degron network	0.2222
p.A618T	HH	haematopoietic and lymphoid tissue	COSMIC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	622:628	Mutation rewiring degron network	0.2222
p.G624A	SIDM00820	Kidney Carcinoma	GDSC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	622:628	Mutation altering degron motif	0.6429
p.G624A	RCC-ER	kidney	COSMIC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	622:628	Mutation altering degron motif	0.6429
p.T286N	SIDM01618	B-Lymphoblastic Leukemia	GDSC	IRESLPALR	DEG_APCC_DBOX_1	289:297	Mutation blocking phosphorylation signal	0.6944
p.T286N	ACH-000942	Leukemia	CCLE	IRESLPALR	DEG_APCC_DBOX_1	289:297	Mutation blocking phosphorylation signal	0.6944
p.A614T	ACH-000061	Lymphoma	CCLE	RAGVYPE	LIG_APCC_ABBAyCdc20_2	622:628	Mutation rewiring degron network	0.1111
p.A614T	HH	haematopoietic and lymphoid tissue	COSMIC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	622:628	Mutation rewiring degron network	0.1111
p.G620A	ACH-002188	Kidney Cancer	CCLE	RAGVYPE	LIG_APCC_ABBAyCdc20_2	622:628	Mutation rewiring degron network	0.2778
p.G620A	RCC-ER	kidney	COSMIC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	622:628	Mutation rewiring degron network	0.2778

Kaplan plot for DNM2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DNM2

UniProt ID: P50570

Entrez ID: 1785

Protein name: Dynamin-2 (EC 3.6.5.5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DNM2 in