DegronMD

Uniprot ID: P50570

Source protein: Dynamin-2

Source gene: DNM2

Class: DEG_APCC_DBOX_1

Location: 289:297

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7781

ASA_SCORE: 56.9

COIL: 0.1504

CONS_SCORE: 0.7035

DSS_SCORE: 0.4287

HELIX: 0.8476

FCONS_SCORE: 1.0651

RIG_SCORE: 0.7637

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q283E	TCGA-62-A471	LUAD	TCGA	IRESLPALR	DEG_APCC_DBOX_1	0.1667
p.Q283E	DO45347	LUAD	ICGC	IRESLPALR	DEG_APCC_DBOX_1	0.1667
p.L296I	TCGA-A6-5661	COAD	TCGA	IRESLPALR	DEG_APCC_DBOX_1	0.6063
p.L296I	TCGA-VQ-A8E3	STAD	TCGA	IRESLPALR	DEG_APCC_DBOX_1	0.6063
p.L296I	DO8634	COAD	ICGC	IRESLPALR	DEG_APCC_DBOX_1	0.6063
p.L296I	DO51759	STAD	ICGC	IRESLPALR	DEG_APCC_DBOX_1	0.6063
p.T280M	TCGA-AJ-A3BH	UCEC	TCGA	IRESLPALR	DEG_APCC_DBOX_1	0.5278
p.T280M	DO41638	UCEC	ICGC	IRESLPALR	DEG_APCC_DBOX_1	0.5278
p.T280M	SIDM01686	Chronic Myelogenous Leukemia	GDSC	IRESLPALR	DEG_APCC_DBOX_1	0.5278
p.T280M	ACH-000462	Leukemia	CCLE	IRESLPALR	DEG_APCC_DBOX_1	0.5278
p.E291D	TCGA-E9-A1RF	BRCA	TCGA	IRESLPALR	DEG_APCC_DBOX_1	0.5647
p.E291D	DO2665	BRCA	ICGC	IRESLPALR	DEG_APCC_DBOX_1	0.5647
p.H288N	TCGA-EE-A29X	SKCM	TCGA	IRESLPALR	DEG_APCC_DBOX_1	0.3056
p.H288N	DO37595	SKCM	ICGC	IRESLPALR	DEG_APCC_DBOX_1	0.3056
p.R290W	TCGA-EO-A3AZ	UCEC	TCGA	IRESLPALR	DEG_APCC_DBOX_1	0.8634
p.R290W	DO50078	UCEC	ICGC	IRESLPALR	DEG_APCC_DBOX_1	0.8634
p.S302C	TCGA-QK-A6II	HNSC	TCGA	IRESLPALR	DEG_APCC_DBOX_1	0.1944
p.S302C	DO50006	HNSC	ICGC	IRESLPALR	DEG_APCC_DBOX_1	0.1944
p.S298N	TCGA-XK-AAJP	PRAD	TCGA	IRESLPALR	DEG_APCC_DBOX_1	0.3056
p.S298N	DO51410	PRAD	ICGC	IRESLPALR	DEG_APCC_DBOX_1	0.3056
p.A295S	DO229029	LICA	ICGC	IRESLPALR	DEG_APCC_DBOX_1	0.6477
p.R297H	DO41199	UCEC	ICGC	IRESLPALR	DEG_APCC_DBOX_1	0.7133
p.Q283R	SIDM00620	Glioblastoma	GDSC	IRESLPALR	DEG_APCC_DBOX_1	0.1667
p.Q283R	D-336MG	central_nervous_system	COSMIC	IRESLPALR	DEG_APCC_DBOX_1	0.1667
p.T286N	SIDM01618	B-Lymphoblastic Leukemia	GDSC	IRESLPALR	DEG_APCC_DBOX_1	0.6944
p.T286N	ACH-000942	Leukemia	CCLE	IRESLPALR	DEG_APCC_DBOX_1	0.6944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P50570	Dynamin-2	DEG_APCC_DBOX_1	289:297	IRESLPALR	APC,CDC20,FZR1	0.7781	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IRESLPALR

Degron related mutations and impact score

Drug responses associated with DNM2 mutations

All proteins holding degron of IRESLPALR