DegronMD

Uniprot ID: P50570

Source protein: Dynamin-2

Source gene: DNM2

Class: LIG_APCC_ABBAyCdc20_2

Location: 622:628

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9947

ASA_SCORE: 70.2429

COIL: 0.7001

CONS_SCORE: 0.6172

DSS_SCORE: 0.4454

HELIX: 0.1971

FCONS_SCORE: 1.4198

RIG_SCORE: 0.725

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E635K	TCGA-A2-A0CX	BRCA	TCGA	RAGVYPE	LIG_APCC_ABBAyCdc20_2	0.1389
p.A638T	TCGA-AG-A002	READ	TCGA	RAGVYPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.V625I	TCGA-AJ-A3BH	UCEC	TCGA	RAGVYPE	LIG_APCC_ABBAyCdc20_2	0.5965
p.P627H	TCGA-FS-A1ZK	SKCM	TCGA	RAGVYPE	LIG_APCC_ABBAyCdc20_2	0.6583
p.S619L	TCGA-FW-A3R5	SKCM	TCGA	RAGVYPE	LIG_APCC_ABBAyCdc20_2	0.25
p.D612N	TCGA-GV-A3JZ	BLCA	TCGA	RAGVYPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.W616C	TCGA-GV-A3JZ	BLCA	TCGA	RAGVYPE	LIG_APCC_ABBAyCdc20_2	0.1667
p.W612C	DO773	BLCA	ICGC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	0.0556
p.E631K	DO2755	BRCA	ICGC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	0.25
p.S615L	DO221126	MALY	ICGC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	0.1389
p.S615L	DO37406	SKCM	ICGC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	0.1389
p.P623H	DO37474	SKCM	ICGC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	0.7694
p.V621I	DO41638	UCEC	ICGC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	0.3056
p.A618T	SIDM00671	T-Cell Non-Hodgkin's Lymphoma	GDSC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	0.2222
p.A618T	HH	haematopoietic_and_lymphoid_tissue	COSMIC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	0.2222
p.G624A	SIDM00820	Kidney Carcinoma	GDSC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	0.6429
p.G624A	RCC-ER	kidney	COSMIC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	0.6429
p.A614T	ACH-000061	Lymphoma	CCLE	RAGVYPE	LIG_APCC_ABBAyCdc20_2	0.1111
p.A614T	HH	haematopoietic_and_lymphoid_tissue	COSMIC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	0.1111
p.G620A	ACH-002188	Kidney Cancer	CCLE	RAGVYPE	LIG_APCC_ABBAyCdc20_2	0.2778
p.G620A	RCC-ER	kidney	COSMIC	RAGVYPE	LIG_APCC_ABBAyCdc20_2	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons