DegronMD

Uniprot ID: Q96L93

Source protein: Kinesin-like protein KIF16B

Source gene: KIF16B

Class: DEG_APCC_DBOX_1

Location: 797:805

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8943

ASA_SCORE: 87.3556

COIL: 0.1003

CONS_SCORE: 0.4081

DSS_SCORE: 0.2999

HELIX: 0.9033

FCONS_SCORE: 1.2853

RIG_SCORE: 0.7983

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E789K	TCGA-68-A59J	LUSC	TCGA	IRESLLRVK	DEG_APCC_DBOX_1	0.1111
p.E789K	TCGA-NC-A5HG	LUSC	TCGA	IRESLLRVK	DEG_APCC_DBOX_1	0.1111
p.E789K	DO49085	LUSC	ICGC	IRESLLRVK	DEG_APCC_DBOX_1	0.1111
p.E789K	DO45448	LUSC	ICGC	IRESLLRVK	DEG_APCC_DBOX_1	0.1111
p.R798W	TCGA-85-A4CL	LUSC	TCGA	IRESLLRVK	DEG_APCC_DBOX_1	0.8634
p.R798W	DO45454	LUSC	ICGC	IRESLLRVK	DEG_APCC_DBOX_1	0.8634
p.D812Y	TCGA-85-A511	LUSC	TCGA	IRESLLRVK	DEG_APCC_DBOX_1	0.1389
p.D812Y	DO45509	LUSC	ICGC	IRESLLRVK	DEG_APCC_DBOX_1	0.1389
p.L802M	TCGA-EE-A3AA	SKCM	TCGA	IRESLLRVK	DEG_APCC_DBOX_1	0.5999
p.L802M	DO222632	MELA	ICGC	IRESLLRVK	DEG_APCC_DBOX_1	0.5999
p.L802M	DO37571	SKCM	ICGC	IRESLLRVK	DEG_APCC_DBOX_1	0.5999
p.R798L	TCGA-HU-A4H4	STAD	TCGA	IRESLLRVK	DEG_APCC_DBOX_1	0.8428
p.R798L	DO47721	STAD	ICGC	IRESLLRVK	DEG_APCC_DBOX_1	0.8428
p.G810R	DO222990	BTCA	ICGC	IRESLLRVK	DEG_APCC_DBOX_1	0.1944
p.D812V	DO218858	SKCA	ICGC	IRESLLRVK	DEG_APCC_DBOX_1	0.1389
p.G811E	SIDM00422	Hodgkin's Lymphoma	GDSC	IRESLLRVK	DEG_APCC_DBOX_1	0.1667
p.G811E	ACH-001203	Lymphoma	CCLE	IRESLLRVK	DEG_APCC_DBOX_1	0.1667
p.G811E	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	IRESLLRVK	DEG_APCC_DBOX_1	0.1667
p.R808S	SIDM00645	Non-Small Cell Lung Carcinoma	GDSC	IRESLLRVK	DEG_APCC_DBOX_1	0.25
p.R808S	NCI-H1355	lung	COSMIC	IRESLLRVK	DEG_APCC_DBOX_1	0.25
p.D793H	SIDM00888	Other Solid Cancers	GDSC	IRESLLRVK	DEG_APCC_DBOX_1	0.2222
p.R803L	SIDM00775	Non-Small Cell Lung Carcinoma	GDSC	IRESLLRVK	DEG_APCC_DBOX_1	0.7316
p.R803L	ACH-000785	Lung Cancer	CCLE	IRESLLRVK	DEG_APCC_DBOX_1	0.7316
p.R803L	NCI-H2126	lung	COSMIC	IRESLLRVK	DEG_APCC_DBOX_1	0.7316
p.R792S	SIDM01018	Hodgkin's Lymphoma	GDSC	IRESLLRVK	DEG_APCC_DBOX_1	0.1944
p.R792S	ACH-000815	Lymphoma	CCLE	IRESLLRVK	DEG_APCC_DBOX_1	0.1944
p.R792S	KM-H2	haematopoietic_and_lymphoid_tissue	COSMIC	IRESLLRVK	DEG_APCC_DBOX_1	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IRESLLRVK

Degron related mutations and impact score

Drug responses associated with KIF16B mutations

All proteins holding degron of IRESLLRVK

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96L93	Kinesin-like protein KIF16B	DEG_APCC_DBOX_1	797:805	IRESLLRVK	APC,CDC20,FZR1	0.8943	More...