DegronMD

Uniprot ID: Q2TAK8

Source protein: PWWP domain-containing DNA repair factor 3A

Source gene: PWWP3A

Class: DEG_APCC_DBOX_1

Location: 652:660

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5292

ASA_SCORE: 22.2444

COIL: 0.2802

CONS_SCORE: 0.8296

DSS_SCORE: 0.0194

HELIX: 0.0472

FCONS_SCORE: 1.2656

RIG_SCORE: 1.0037

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R647H	SIDM00222	Mesothelioma	GDSC	IRFILDVLL	DEG_APCC_DBOX_1	0.1944
p.A668V	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	IRFILDVLL	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2TAK8	PWWP domain-containing DNA repair factor 3A	DEG_APCC_DBOX_1	652:660	IRFILDVLL	APC,CDC20,FZR1	0.5292	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons