DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
IRFNLMAVV
Uniprot ID:
Q92560
Source protein:
Ubiquitin carboxyl-terminal hydrolase BAP1
Source gene:
BAP1
Class:
DEG_APCC_DBOX_1
Location:
226:234
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.7925
ASA_SCORE:
17.0778
COIL:
0.1709
CONS_SCORE:
0.7262
DSS_SCORE:
0.1156
HELIX:
0.0188
FCONS_SCORE:
1.5602
RIG_SCORE:
0.88
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R227H
TCGA-21-1078
LUSC
TCGA
IRFNLMAVV
DEG_APCC_DBOX_1
0.8244
p.R227H
DO26653
LUSC
ICGC
IRFNLMAVV
DEG_APCC_DBOX_1
0.8244
p.R227H
SIDM00433
T-Lymphoblastic Leukemia
GDSC
IRFNLMAVV
DEG_APCC_DBOX_1
0.8244
p.R227H
ACH-000795
Leukemia
CCLE
IRFNLMAVV
DEG_APCC_DBOX_1
0.8244
p.R227H
MOLT-13
haematopoietic_and_lymphoid_tissue
COSMIC
IRFNLMAVV
DEG_APCC_DBOX_1
0.8244
p.R237C
TCGA-BH-A0GY
BRCA
TCGA
IRFNLMAVV
DEG_APCC_DBOX_1
0.25
p.D225H
TCGA-CU-A0YR
BLCA
TCGA
IRFNLMAVV
DEG_APCC_DBOX_1
0.3056
p.D225H
DO449
BLCA
ICGC
IRFNLMAVV
DEG_APCC_DBOX_1
0.3056
p.P235L
TCGA-DI-A1BU
UCEC
TCGA
IRFNLMAVV
DEG_APCC_DBOX_1
0.3056
p.P235L
DO42023
UCEC
ICGC
IRFNLMAVV
DEG_APCC_DBOX_1
0.3056
p.D236N
TCGA-EO-A3AV
UCEC
TCGA
IRFNLMAVV
DEG_APCC_DBOX_1
0.2778
p.M231T
DO48370
BLCA
ICGC
IRFNLMAVV
DEG_APCC_DBOX_1
0.6312
p.R234P
DO225002
BRCA
ICGC
IRFNLMAVV
DEG_APCC_DBOX_1
0.7512
p.R234H
DO218347
BRCA
ICGC
IRFNLMAVV
DEG_APCC_DBOX_1
0.8244
p.R234H
DO219773
UCEC
ICGC
IRFNLMAVV
DEG_APCC_DBOX_1
0.8244
p.D225N
DO1071
BRCA
ICGC
IRFNLMAVV
DEG_APCC_DBOX_1
0.3056
p.L227M
DO229009
LICA
ICGC
IRFNLMAVV
DEG_APCC_DBOX_1
0.711
p.K231E
DO48677
LIRI
ICGC
IRFNLMAVV
DEG_APCC_DBOX_1
0.7022
p.Q235L
DO48677
LIRI
ICGC
IRFNLMAVV
DEG_APCC_DBOX_1
0.3056
p.L227P
DO47950
STAD
ICGC
IRFNLMAVV
DEG_APCC_DBOX_1
0.7582
p.L244P
DO42568
UCEC
ICGC
IRFNLMAVV
DEG_APCC_DBOX_1
0.0556
p.L230Q
ACH-000600
Kidney Cancer
CCLE
IRFNLMAVV
DEG_APCC_DBOX_1
0.7765
Drug responses associated with BAP1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of IRFNLMAVV
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q92560
Ubiquitin carboxyl-terminal hydrolase BAP1
DEG_APCC_DBOX_1
226:234
IRFNLMAVV
APC,CDC20,FZR1
0.7925
More...