DegronMD - Q92560(BAP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R227H	TCGA-21-1078	LUSC	TCGA	IRFNLMAVV	DEG_APCC_DBOX_1	226:234	Mutation altering degron motif	0.8244
p.R227H	DO26653	LUSC	ICGC	IRFNLMAVV	DEG_APCC_DBOX_1	226:234	Mutation altering degron motif	0.8244
p.R227H	SIDM00433	T-Lymphoblastic Leukemia	GDSC	IRFNLMAVV	DEG_APCC_DBOX_1	226:234	Mutation altering degron motif	0.8244
p.R227H	ACH-000795	Leukemia	CCLE	IRFNLMAVV	DEG_APCC_DBOX_1	226:234	Mutation altering degron motif	0.8244
p.R227H	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	IRFNLMAVV	DEG_APCC_DBOX_1	226:234	Mutation altering degron motif	0.8244
p.T487S	TCGA-25-1313	OV	TCGA	PSPTPSNE	DEG_SCF_FBW7_2	484:491	Mutation altering degron motif	0.8227
p.A496T	TCGA-AP-A1DK	UCEC	TCGA	PSPTPSNE	DEG_SCF_FBW7_2	484:491	Mutation rewiring degron network	0.1944
p.A496T	TCGA-AX-A0J1	UCEC	TCGA	PSPTPSNE	DEG_SCF_FBW7_2	484:491	Mutation rewiring degron network	0.1944
p.S497P	TCGA-AX-A2HG	UCEC	TCGA	PSPTPSNE	DEG_SCF_FBW7_2	484:491	Mutation rewiring degron network	0.1667
p.T495M	TCGA-B5-A11Y	UCEC	TCGA	PSPTPSNE	DEG_SCF_FBW7_2	484:491	Mutation rewiring degron network	0.2222
p.R237C	TCGA-BH-A0GY	BRCA	TCGA	IRFNLMAVV	DEG_APCC_DBOX_1	226:234	Mutation rewiring degron network	0.25
p.P479L	TCGA-CK-4951	COAD	TCGA	PSPTPSNE	DEG_SCF_FBW7_2	484:491	Mutation rewiring degron network	0.1944
p.D225H	TCGA-CU-A0YR	BLCA	TCGA	IRFNLMAVV	DEG_APCC_DBOX_1	226:234	Mutation rewiring degron network	0.3056
p.D225H	DO449	BLCA	ICGC	IRFNLMAVV	DEG_APCC_DBOX_1	226:234	Mutation rewiring degron network	0.3056
p.P235L	TCGA-DI-A1BU	UCEC	TCGA	IRFNLMAVV	DEG_APCC_DBOX_1	226:234	Mutation rewiring degron network	0.3056
p.P235L	DO42023	UCEC	ICGC	IRFNLMAVV	DEG_APCC_DBOX_1	226:234	Mutation rewiring degron network	0.3056
p.D236N	TCGA-EO-A3AV	UCEC	TCGA	IRFNLMAVV	DEG_APCC_DBOX_1	226:234	Mutation rewiring degron network	0.2778
p.M231T	DO48370	BLCA	ICGC	IRFNLMAVV	DEG_APCC_DBOX_1	226:234	Mutation altering degron motif	0.6312
p.R234P	DO225002	BRCA	ICGC	IRFNLMAVV	DEG_APCC_DBOX_1	226:234	Mutation altering degron motif	0.7512
p.R494C	DO225337	BRCA	ICGC	PSPTPSNE	DEG_SCF_FBW7_2	484:491	Mutation rewiring degron network	0.25
p.R494C	DO229388	BTCA	ICGC	PSPTPSNE	DEG_SCF_FBW7_2	484:491	Mutation rewiring degron network	0.25
p.R494C	DO10324	COAD	ICGC	PSPTPSNE	DEG_SCF_FBW7_2	484:491	Mutation rewiring degron network	0.25
p.R234H	DO218347	BRCA	ICGC	IRFNLMAVV	DEG_APCC_DBOX_1	226:234	Mutation altering degron motif	0.8244
p.R234H	DO219773	UCEC	ICGC	IRFNLMAVV	DEG_APCC_DBOX_1	226:234	Mutation altering degron motif	0.8244
p.D225N	DO1071	BRCA	ICGC	IRFNLMAVV	DEG_APCC_DBOX_1	226:234	Mutation rewiring degron network	0.3056
p.P501A	DO233888	GACA	ICGC	PSPTPSNE	DEG_SCF_FBW7_2	484:491	Mutation rewiring degron network	0.0556
p.L227M	DO229009	LICA	ICGC	IRFNLMAVV	DEG_APCC_DBOX_1	226:234	Mutation altering degron motif	0.711
p.K231E	DO48677	LIRI	ICGC	IRFNLMAVV	DEG_APCC_DBOX_1	226:234	Mutation altering degron motif	0.7022
p.Q235L	DO48677	LIRI	ICGC	IRFNLMAVV	DEG_APCC_DBOX_1	226:234	Mutation rewiring degron network	0.3056
p.N486S	DO233582	RECA	ICGC	PSPTPSNE	DEG_SCF_FBW7_2	484:491	Mutation altering degron motif	0.7069
p.L227P	DO47950	STAD	ICGC	IRFNLMAVV	DEG_APCC_DBOX_1	226:234	Mutation altering degron motif	0.7582
p.T477M	DO40889	UCEC	ICGC	PSPTPSNE	DEG_SCF_FBW7_2	484:491	Mutation rewiring degron network	0.1389
p.A478T	DO42033	UCEC	ICGC	PSPTPSNE	DEG_SCF_FBW7_2	484:491	Mutation rewiring degron network	0.1667
p.A478T	DO41199	UCEC	ICGC	PSPTPSNE	DEG_SCF_FBW7_2	484:491	Mutation rewiring degron network	0.1667
p.R500Q	DO41638	UCEC	ICGC	PSPTPSNE	DEG_SCF_FBW7_2	484:491	Mutation rewiring degron network	0.0833
p.R490C	DO41871	UCEC	ICGC	PSPTPSNE	DEG_SCF_FBW7_2	484:491	Mutation altering degron motif	0.8301
p.R490C	CW-2	large intestine	COSMIC	PSPTPSNE	DEG_SCF_FBW7_2	484:491	Mutation altering degron motif	0.8301
p.L244P	DO42568	UCEC	ICGC	IRFNLMAVV	DEG_APCC_DBOX_1	226:234	Mutation rewiring degron network	0.0556
p.S479P	DO41337	UCEC	ICGC	PSPTPSNE	DEG_SCF_FBW7_2	484:491	Mutation rewiring degron network	0.1944
p.N490K	SIDM01114	Non-Cancerous	GDSC	PSPTPSNE	DEG_SCF_FBW7_2	484:491	Mutation altering degron motif	0.5806
p.N490K	ACH-001383	Prostate Cancer	CCLE	PSPTPSNE	DEG_SCF_FBW7_2	484:491	Mutation altering degron motif	0.5806
p.N490K	PWR-1E	prostate	COSMIC	PSPTPSNE	DEG_SCF_FBW7_2	484:491	Mutation altering degron motif	0.5806
p.S482L	SIDM00537	Colorectal Carcinoma	GDSC	PSPTPSNE	DEG_SCF_FBW7_2	484:491	Mutation rewiring degron network	0.2778
p.S482L	ACH-000982	Colon/Colorectal Cancer	CCLE	PSPTPSNE	DEG_SCF_FBW7_2	484:491	Mutation rewiring degron network	0.2778
p.S482L	ACH-001345	Colon/Colorectal Cancer	CCLE	PSPTPSNE	DEG_SCF_FBW7_2	484:491	Mutation rewiring degron network	0.2778
p.S482L	GP5d	large intestine	COSMIC	PSPTPSNE	DEG_SCF_FBW7_2	484:491	Mutation rewiring degron network	0.2778
p.G500D	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	PSPTPSNE	DEG_SCF_FBW7_2	484:491	Mutation rewiring degron network	0.0833
p.G500D	ACH-000925	Lung Cancer	CCLE	PSPTPSNE	DEG_SCF_FBW7_2	484:491	Mutation rewiring degron network	0.0833
p.L230Q	ACH-000600	Kidney Cancer	CCLE	IRFNLMAVV	DEG_APCC_DBOX_1	226:234	Mutation altering degron motif	0.7765
p.N497S	SNU-C5	large intestine	COSMIC	PSPTPSNE	DEG_SCF_FBW7_2	484:491	Mutation rewiring degron network	0.1667
p.T499M	HCT-15	large intestine	COSMIC	PSPTPSNE	DEG_SCF_FBW7_2	484:491	Mutation rewiring degron network	0.1111

Kaplan plot for BAP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

BAP1

UniProt ID: Q92560

Entrez ID: 8314

Protein name: Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1) (Cerebral protein 6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for BAP1 in