DegronMD

Uniprot ID: Q92560

Source protein: Ubiquitin carboxyl-terminal hydrolase BAP1

Source gene: BAP1

Class: DEG_SCF_FBW7_2

Location: 484:491

E3 ligase: FBXW7

DEGRON score: 0.9815

ASA_SCORE: 86.725

COIL: 0.9244

CONS_SCORE: 0.458

DSS_SCORE: 0.7778

HELIX: 0.0561

FCONS_SCORE: 1.1285

RIG_SCORE: 0.524

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T487S	TCGA-25-1313	OV	TCGA	PSPTPSNE	DEG_SCF_FBW7_2	0.8227
p.A496T	TCGA-AP-A1DK	UCEC	TCGA	PSPTPSNE	DEG_SCF_FBW7_2	0.1944
p.A496T	TCGA-AX-A0J1	UCEC	TCGA	PSPTPSNE	DEG_SCF_FBW7_2	0.1944
p.S497P	TCGA-AX-A2HG	UCEC	TCGA	PSPTPSNE	DEG_SCF_FBW7_2	0.1667
p.T495M	TCGA-B5-A11Y	UCEC	TCGA	PSPTPSNE	DEG_SCF_FBW7_2	0.2222
p.P479L	TCGA-CK-4951	COAD	TCGA	PSPTPSNE	DEG_SCF_FBW7_2	0.1944
p.R494C	DO225337	BRCA	ICGC	PSPTPSNE	DEG_SCF_FBW7_2	0.25
p.R494C	DO229388	BTCA	ICGC	PSPTPSNE	DEG_SCF_FBW7_2	0.25
p.R494C	DO10324	COAD	ICGC	PSPTPSNE	DEG_SCF_FBW7_2	0.25
p.P501A	DO233888	GACA	ICGC	PSPTPSNE	DEG_SCF_FBW7_2	0.0556
p.N486S	DO233582	RECA	ICGC	PSPTPSNE	DEG_SCF_FBW7_2	0.7069
p.T477M	DO40889	UCEC	ICGC	PSPTPSNE	DEG_SCF_FBW7_2	0.1389
p.A478T	DO42033	UCEC	ICGC	PSPTPSNE	DEG_SCF_FBW7_2	0.1667
p.A478T	DO41199	UCEC	ICGC	PSPTPSNE	DEG_SCF_FBW7_2	0.1667
p.R500Q	DO41638	UCEC	ICGC	PSPTPSNE	DEG_SCF_FBW7_2	0.0833
p.R490C	DO41871	UCEC	ICGC	PSPTPSNE	DEG_SCF_FBW7_2	0.8301
p.R490C	CW-2	large_intestine	COSMIC	PSPTPSNE	DEG_SCF_FBW7_2	0.8301
p.S479P	DO41337	UCEC	ICGC	PSPTPSNE	DEG_SCF_FBW7_2	0.1944
p.N490K	SIDM01114	Non-Cancerous	GDSC	PSPTPSNE	DEG_SCF_FBW7_2	0.5806
p.N490K	ACH-001383	Prostate Cancer	CCLE	PSPTPSNE	DEG_SCF_FBW7_2	0.5806
p.N490K	PWR-1E	prostate	COSMIC	PSPTPSNE	DEG_SCF_FBW7_2	0.5806
p.S482L	SIDM00537	Colorectal Carcinoma	GDSC	PSPTPSNE	DEG_SCF_FBW7_2	0.2778
p.S482L	ACH-000982	Colon/Colorectal Cancer	CCLE	PSPTPSNE	DEG_SCF_FBW7_2	0.2778
p.S482L	ACH-001345	Colon/Colorectal Cancer	CCLE	PSPTPSNE	DEG_SCF_FBW7_2	0.2778
p.S482L	GP5d	large_intestine	COSMIC	PSPTPSNE	DEG_SCF_FBW7_2	0.2778
p.G500D	SIDM01510	Non-Small Cell Lung Carcinoma	GDSC	PSPTPSNE	DEG_SCF_FBW7_2	0.0833
p.G500D	ACH-000925	Lung Cancer	CCLE	PSPTPSNE	DEG_SCF_FBW7_2	0.0833
p.N497S	SNU-C5	large_intestine	COSMIC	PSPTPSNE	DEG_SCF_FBW7_2	0.1667
p.T499M	HCT-15	large_intestine	COSMIC	PSPTPSNE	DEG_SCF_FBW7_2	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSPTPSNE

Degron related mutations and impact score

Drug responses associated with BAP1 mutations

All proteins holding degron of PSPTPSNE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92560	Ubiquitin carboxyl-terminal hydrolase BAP1	DEG_SCF_FBW7_2	484:491	PSPTPSNE	FBXW7	0.9815	More...