DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PSPTPSNE
Uniprot ID:
Q92560
Source protein:
Ubiquitin carboxyl-terminal hydrolase BAP1
Source gene:
BAP1
Class:
DEG_SCF_FBW7_2
Location:
484:491
E3 ligase:
FBXW7
DEGRON score:
0.9815
ASA_SCORE:
86.725
COIL:
0.9244
CONS_SCORE:
0.458
DSS_SCORE:
0.7778
HELIX:
0.0561
FCONS_SCORE:
1.1285
RIG_SCORE:
0.524
Degron related mutations and impact score
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Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.R490C
DO41871
UCEC
ICGC
PSPTPSNE
DEG_SCF_FBW7_2
0.8301
p.R490C
CW-2
large_intestine
COSMIC
PSPTPSNE
DEG_SCF_FBW7_2
0.8301
p.T487S
TCGA-25-1313
OV
TCGA
PSPTPSNE
DEG_SCF_FBW7_2
0.8227
p.N486S
DO233582
RECA
ICGC
PSPTPSNE
DEG_SCF_FBW7_2
0.7069
p.N490K
SIDM01114
Non-Cancerous
GDSC
PSPTPSNE
DEG_SCF_FBW7_2
0.5806
p.N490K
ACH-001383
Prostate Cancer
CCLE
PSPTPSNE
DEG_SCF_FBW7_2
0.5806
p.N490K
PWR-1E
prostate
COSMIC
PSPTPSNE
DEG_SCF_FBW7_2
0.5806
p.S482L
SIDM00537
Colorectal Carcinoma
GDSC
PSPTPSNE
DEG_SCF_FBW7_2
0.2778
p.S482L
ACH-000982
Colon/Colorectal Cancer
CCLE
PSPTPSNE
DEG_SCF_FBW7_2
0.2778
p.S482L
ACH-001345
Colon/Colorectal Cancer
CCLE
PSPTPSNE
DEG_SCF_FBW7_2
0.2778
p.S482L
GP5d
large_intestine
COSMIC
PSPTPSNE
DEG_SCF_FBW7_2
0.2778
p.R494C
DO225337
BRCA
ICGC
PSPTPSNE
DEG_SCF_FBW7_2
0.25
p.R494C
DO229388
BTCA
ICGC
PSPTPSNE
DEG_SCF_FBW7_2
0.25
p.R494C
DO10324
COAD
ICGC
PSPTPSNE
DEG_SCF_FBW7_2
0.25
p.T495M
TCGA-B5-A11Y
UCEC
TCGA
PSPTPSNE
DEG_SCF_FBW7_2
0.2222
p.A496T
TCGA-AP-A1DK
UCEC
TCGA
PSPTPSNE
DEG_SCF_FBW7_2
0.1944
p.A496T
TCGA-AX-A0J1
UCEC
TCGA
PSPTPSNE
DEG_SCF_FBW7_2
0.1944
p.P479L
TCGA-CK-4951
COAD
TCGA
PSPTPSNE
DEG_SCF_FBW7_2
0.1944
p.S479P
DO41337
UCEC
ICGC
PSPTPSNE
DEG_SCF_FBW7_2
0.1944
p.S497P
TCGA-AX-A2HG
UCEC
TCGA
PSPTPSNE
DEG_SCF_FBW7_2
0.1667
p.A478T
DO42033
UCEC
ICGC
PSPTPSNE
DEG_SCF_FBW7_2
0.1667
p.A478T
DO41199
UCEC
ICGC
PSPTPSNE
DEG_SCF_FBW7_2
0.1667
p.N497S
SNU-C5
large_intestine
COSMIC
PSPTPSNE
DEG_SCF_FBW7_2
0.1667
p.T477M
DO40889
UCEC
ICGC
PSPTPSNE
DEG_SCF_FBW7_2
0.1389
p.T499M
HCT-15
large_intestine
COSMIC
PSPTPSNE
DEG_SCF_FBW7_2
0.1111
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Drug responses associated with BAP1 mutations
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Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
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All proteins holding degron of PSPTPSNE
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Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q92560
Ubiquitin carboxyl-terminal hydrolase BAP1
DEG_SCF_FBW7_2
484:491
PSPTPSNE
FBXW7
0.9815
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