DegronMD

Uniprot ID: Q96PC5

Source protein: Melanoma inhibitory activity protein 2

Source gene: MIA2

Class: DEG_APCC_DBOX_1

Location: 1307:1315

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9888

ASA_SCORE: 66.6333

COIL: 0.9547

CONS_SCORE: 0

DSS_SCORE: 0.473

HELIX: 0.0169

FCONS_SCORE: 0

RIG_SCORE: 0.7121

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1323G	SIDM00406	B-Cell Non-Hodgkin's Lymphoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	0.1111
p.R1323G	SIDM00944	Colorectal Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	0.1111
p.R1323G	SIDM00620	Glioblastoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	0.1111
p.R1323G	SIDM00222	Mesothelioma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	0.1111
p.R1323G	SIDM00759	Non-Small Cell Lung Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	0.1111
p.R1323G	SIDM00426	Rhabdomyosarcoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	0.1111
p.R1323G	SIDM00705	Non-Cancerous	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	0.1111
p.R1323G	SIDM00198	Ewing's Sarcoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	0.1111
p.R1323G	SIDM01248	Thyroid Gland Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	0.1111
p.R1323G	SIDM01129	Small Cell Lung Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	0.1111
p.R1323G	SIDM00623	Other Blood Cancers	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	0.1111
p.R1323G	SIDM00042	Pancreatic Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	0.1111
p.R1323G	SIDM00190	Melanoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	0.1111
p.R1323G	SIDM00769	Non-Small Cell Lung Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	0.1111
p.R1323G	SIDM01149	Small Cell Lung Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	0.1111
p.R1323G	SIDM00444	Esophageal Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	0.1111
p.R1323G	SIDM00696	Non-Cancerous	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	0.1111
p.R1323G	SIDM00772	Breast Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	0.1111
p.R1323G	SIDM00402	Bladder Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	0.1111
p.R1323G	SIDM00136	Colorectal Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	0.1111
p.R1323G	SIDM00103	Mesothelioma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	0.1111
p.R1323G	SIDM00853	Other Sarcomas	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	0.1111
p.R1323G	SIDM01082	Oral Cavity Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	0.1111
p.R1323G	SIDM00483	Esophageal Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	0.1111
p.R1323G	SIDM00420	Bladder Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	0.1111
p.R1323G	SIDM00101	Mesothelioma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	0.1111
p.R1323G	SIDM00508	Squamous Cell Lung Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	0.1111
p.R1323G	SIDM01187	Breast Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	0.1111
p.R1323G	SIDM01715	Non-Cancerous	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	0.1111
p.R1323G	SIDM01140	Ovarian Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	0.1111
p.R1323G	SIDM00137	Non-Small Cell Lung Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	0.1111
p.R1323G	SIDM00515	Melanoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	0.1111
p.R1323G	SIDM01624	Bladder Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	0.1111
p.R1323G	SIDM01522	B-Lymphoblastic Leukemia	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	0.1111
p.R1323G	SIDM01746	Osteosarcoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	0.1111
p.R1323G	SIDM01529	Bladder Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	0.1111
p.R1323G	SIDM01591	Breast Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	0.1111
p.R1323G	SIDM01167	Thyroid Gland Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	0.1111
p.P1299L	NKM-1	haematopoietic_and_lymphoid_tissue	COSMIC	IRGPLFPVD	DEG_APCC_DBOX_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IRGPLFPVD

Degron related mutations and impact score

Drug responses associated with MIA2 mutations

All proteins holding degron of IRGPLFPVD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96PC5	Melanoma inhibitory activity protein 2	DEG_APCC_DBOX_1	1307:1315	IRGPLFPVD	APC,CDC20,FZR1	0.9888	More...