DegronMD - Q96PC5(MIA2)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D149V	TCGA-50-5944	LUAD	TCGA	IYPYEE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.25
p.S153C	TCGA-90-7769	LUSC	TCGA	IYPYEE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.1389
p.Q488E	TCGA-BH-A18J	BRCA	TCGA	NEETGE	DEG_Kelch_Keap1_1	494:499	Mutation rewiring degron network	0.1667
p.K151T	TCGA-CA-6718	COAD	TCGA	IYPYEE	LIG_APCC_ABBA_1	141:146	Mutation substituting flanking lysine	0.3056
p.S152F	TCGA-D3-A1Q6	SKCM	TCGA	IYPYEE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.1667
p.Y155H	TCGA-D8-A1XK	BRCA	TCGA	IYPYEE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.0833
p.P143L	TCGA-DA-A3F8	SKCM	TCGA	IYPYEE	LIG_APCC_ABBA_1	141:146	Mutation altering degron motif	0.6471
p.N489Y	TCGA-EY-A1GI	UCEC	TCGA	NEETGE	DEG_Kelch_Keap1_1	494:499	Mutation rewiring degron network	0.1944
p.S152Y	TCGA-F5-6814	READ	TCGA	IYPYEE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.1667
p.D149Y	TCGA-VS-A8EK	CESC	TCGA	IYPYEE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.25
p.T509A	DO223592	BLCA	ICGC	NEETGE	DEG_Kelch_Keap1_1	494:499	Mutation rewiring degron network	0.0556
p.Y154H	DO4749	BRCA	ICGC	IYPYEE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.1111
p.Q487E	DO4527	BRCA	ICGC	NEETGE	DEG_Kelch_Keap1_1	494:499	Mutation rewiring degron network	0.1389
p.D148Y	DO51623	CESC	ICGC	IYPYEE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.2778
p.K150T	DO7801	COAD	ICGC	IYPYEE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.2222
p.I140M	DO229010	COCA	ICGC	IYPYEE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.3056
p.I140M	DO229013	COCA	ICGC	IYPYEE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.3056
p.I140M	DO229016	COCA	ICGC	IYPYEE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.3056
p.I140M	DO229003	COCA	ICGC	IYPYEE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.3056
p.I140M	DO229005	COCA	ICGC	IYPYEE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.3056
p.I140M	DO228941	LICA	ICGC	IYPYEE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.3056
p.I140M	DO229047	LICA	ICGC	IYPYEE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.3056
p.D148V	DO24379	LUAD	ICGC	IYPYEE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.2778
p.N133K	DO231078	LUSC	ICGC	IYPYEE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.1111
p.S152C	DO26822	LUSC	ICGC	IYPYEE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.1667
p.E155D	DO222546	MELA	ICGC	IYPYEE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.0833
p.E149K	DO222632	MELA	ICGC	IYPYEE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.25
p.G497E	DO222837	MELA	ICGC	NEETGE	DEG_Kelch_Keap1_1	494:499	Mutation altering degron motif	0.7199
p.G134S	DO227759	PBCA	ICGC	IYPYEE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.1389
p.S151Y	DO36556	READ	ICGC	IYPYEE	LIG_APCC_ABBA_1	141:146	Mutation substituting flanking lysine	0.3056
p.P142L	DO37418	SKCM	ICGC	IYPYEE	LIG_APCC_ABBA_1	141:146	Mutation altering degron motif	0.7582
p.S151F	DO37450	SKCM	ICGC	IYPYEE	LIG_APCC_ABBA_1	141:146	Mutation substituting flanking lysine	0.3056
p.N488Y	DO41211	UCEC	ICGC	NEETGE	DEG_Kelch_Keap1_1	494:499	Mutation rewiring degron network	0.1667
p.R1323G	SIDM00406	B-Cell Non-Hodgkin's Lymphoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.1111
p.R1323G	SIDM00944	Colorectal Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.1111
p.R1323G	SIDM00620	Glioblastoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.1111
p.R1323G	SIDM00222	Mesothelioma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.1111
p.R1323G	SIDM00759	Non-Small Cell Lung Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.1111
p.R1323G	SIDM00426	Rhabdomyosarcoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.1111
p.R1323G	SIDM00705	Non-Cancerous	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.1111
p.R1323G	SIDM00198	Ewing's Sarcoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.1111
p.R1323G	SIDM01248	Thyroid Gland Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.1111
p.R1323G	SIDM01129	Small Cell Lung Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.1111
p.R1323G	SIDM00623	Other Blood Cancers	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.1111
p.R1323G	SIDM00042	Pancreatic Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.1111
p.R1323G	SIDM00190	Melanoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.1111
p.R1323G	SIDM00769	Non-Small Cell Lung Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.1111
p.R1323G	SIDM01149	Small Cell Lung Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.1111
p.R1323G	SIDM00444	Esophageal Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.1111
p.R1323G	SIDM00696	Non-Cancerous	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.1111
p.R1323G	SIDM00772	Breast Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.1111
p.R1323G	SIDM00402	Bladder Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.1111
p.R1323G	SIDM00136	Colorectal Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.1111
p.R1323G	SIDM00103	Mesothelioma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.1111
p.R1323G	SIDM00853	Other Sarcomas	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.1111
p.R1323G	SIDM01082	Oral Cavity Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.1111
p.R1323G	SIDM00483	Esophageal Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.1111
p.R1323G	SIDM00420	Bladder Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.1111
p.R1323G	SIDM00101	Mesothelioma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.1111
p.R1323G	SIDM00508	Squamous Cell Lung Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.1111
p.R1323G	SIDM01187	Breast Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.1111
p.R1323G	SIDM01715	Non-Cancerous	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.1111
p.R1323G	SIDM01140	Ovarian Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.1111
p.R1323G	SIDM00137	Non-Small Cell Lung Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.1111
p.R1323G	SIDM00515	Melanoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.1111
p.R1323G	SIDM01624	Bladder Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.1111
p.R1323G	SIDM01522	B-Lymphoblastic Leukemia	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.1111
p.R1323G	SIDM01746	Osteosarcoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.1111
p.R1323G	SIDM01529	Bladder Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.1111
p.R1323G	SIDM01591	Breast Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.1111
p.R1323G	SIDM01167	Thyroid Gland Carcinoma	GDSC	IRGPLFPVD	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.1111
p.E496G	SIDM00955	Melanoma	GDSC	NEETGE	DEG_Kelch_Keap1_1	494:499	Mutation altering degron motif	0.7199
p.E496G	SIDM00085	Glioma	GDSC	NEETGE	DEG_Kelch_Keap1_1	494:499	Mutation altering degron motif	0.7199
p.I141V	SIDM00767	Small Cell Lung Carcinoma	GDSC	IYPYEE	LIG_APCC_ABBA_1	141:146	Mutation altering degron motif	0.5965
p.I141V	ACH-001136	Lung Cancer	CCLE	IYPYEE	LIG_APCC_ABBA_1	141:146	Mutation altering degron motif	0.5965
p.I141V	NCI-H187	lung	COSMIC	IYPYEE	LIG_APCC_ABBA_1	141:146	Mutation altering degron motif	0.5965
p.E156A	ACH-002710	Sarcoma	CCLE	IYPYEE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.0556
p.D501N	HCC2998	large intestine	COSMIC	NEETGE	DEG_Kelch_Keap1_1	494:499	Mutation rewiring degron network	0.2778
p.S136A	LN-18	central nervous system	COSMIC	IYPYEE	LIG_APCC_ABBA_1	141:146	Mutation rewiring degron network	0.1944
p.S141N	NCI-H716	large intestine	COSMIC	IYPYEE	LIG_APCC_ABBA_1	141:146	Mutation altering degron motif	0.7069
p.S146N	NCI-H716	large intestine	COSMIC	IYPYEE	LIG_APCC_ABBA_1	141:146	Mutation altering degron motif	0.7069
p.H506Y	SNU-398	liver	COSMIC	NEETGE	DEG_Kelch_Keap1_1	494:499	Mutation rewiring degron network	0.1389
p.S141A	LN-18	central nervous system	COSMIC	IYPYEE	LIG_APCC_ABBA_1	141:146	Mutation altering degron motif	0.7588
p.D489N	HCC2998	large intestine	COSMIC	NEETGE	DEG_Kelch_Keap1_1	494:499	Mutation rewiring degron network	0.1944
p.P505H	LS-180	large intestine	COSMIC	NEETGE	DEG_Kelch_Keap1_1	494:499	Mutation rewiring degron network	0.1667
p.D506N	HCC2998	large intestine	COSMIC	NEETGE	DEG_Kelch_Keap1_1	494:499	Mutation rewiring degron network	0.1389
p.P1299L	NKM-1	haematopoietic and lymphoid tissue	COSMIC	IRGPLFPVD	DEG_APCC_DBOX_1	1307:1315	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MIA2

UniProt ID: Q96PC5

Entrez ID: 4253

Protein name: Melanoma inhibitory activity protein 2 (MIA protein 2) (CTAGE family member 5 ER export factor) (Cutaneous T-cell lymphoma-associated antigen 5) (Meningioma-expressed antigen 6/11)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for MIA2 in