DegronMD

Uniprot ID: Q96PC5

Source protein: Melanoma inhibitory activity protein 2

Source gene: MIA2

Class: DEG_Kelch_Keap1_1

Location: 494:499

E3 ligase: KEAP1

DEGRON score: 0.9627

ASA_SCORE: 98.1167

COIL: 0.7795

CONS_SCORE: 0.4798

DSS_SCORE: 0.4646

HELIX: 0.1447

FCONS_SCORE: 1.1434

RIG_SCORE: 0.7571

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q488E	TCGA-BH-A18J	BRCA	TCGA	NEETGE	DEG_Kelch_Keap1_1	0.1667
p.N489Y	TCGA-EY-A1GI	UCEC	TCGA	NEETGE	DEG_Kelch_Keap1_1	0.1944
p.T509A	DO223592	BLCA	ICGC	NEETGE	DEG_Kelch_Keap1_1	0.0556
p.Q487E	DO4527	BRCA	ICGC	NEETGE	DEG_Kelch_Keap1_1	0.1389
p.G497E	DO222837	MELA	ICGC	NEETGE	DEG_Kelch_Keap1_1	0.7199
p.N488Y	DO41211	UCEC	ICGC	NEETGE	DEG_Kelch_Keap1_1	0.1667
p.E496G	SIDM00955	Melanoma	GDSC	NEETGE	DEG_Kelch_Keap1_1	0.7199
p.E496G	SIDM00085	Glioma	GDSC	NEETGE	DEG_Kelch_Keap1_1	0.7199
p.D501N	HCC2998	large_intestine	COSMIC	NEETGE	DEG_Kelch_Keap1_1	0.2778
p.H506Y	SNU-398	liver	COSMIC	NEETGE	DEG_Kelch_Keap1_1	0.1389
p.D489N	HCC2998	large_intestine	COSMIC	NEETGE	DEG_Kelch_Keap1_1	0.1944
p.P505H	LS-180	large_intestine	COSMIC	NEETGE	DEG_Kelch_Keap1_1	0.1667
p.D506N	HCC2998	large_intestine	COSMIC	NEETGE	DEG_Kelch_Keap1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q96PC5	Melanoma inhibitory activity protein 2	DEG_Kelch_Keap1_1	494:499	NEETGE	KEAP1	0.9627	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons